ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1293286
Target Type SINGLE PROTEIN
Preferred Name Polyadenylate-binding protein 1
Synonyms PAB1 | PABP-1 | PABP1 | PABPC1 | PABPC2 | Poly(A)-binding protein 1 | Polyadenylate-binding protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Polyadenylate-binding protein 1 SINGLE PROTEIN P11940

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000070756
Ensembl ENSG00000070756
GO Cellular Component GO:0005634 (nucleus)
GO:0005681 (spliceosomal complex)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005925 (focal adhesion)
GO:0010494 (cytoplasmic stress granule)
GO:0016020 (membrane)
GO:0030529 (intracellular ribonucleoprotein complex)
GO:0036464 (cytoplasmic ribonucleoprotein granule)
GO:0070062 (extracellular exosome)
GO:0071013 (catalytic step 2 spliceosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003676 (nucleic acid binding)
GO:0003723 (RNA binding)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0008143 (poly(A) binding)
GO:0008266 (poly(U) RNA binding)
GO:0008494 (translation activator activity)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0000184 (nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)
GO:0000289 (nuclear-transcribed mRNA poly(A) tail shortening)
GO:0000398 (mRNA splicing, via spliceosome)
GO:0006378 (mRNA polyadenylation)
GO:0006397 (mRNA processing)
GO:0006413 (translational initiation)
GO:0008380 (RNA splicing)
GO:0031047 (gene silencing by RNA)
GO:0043488 (regulation of mRNA stability)
GO:0045070 (positive regulation of viral genome replication)
GO:0045727 (positive regulation of translation)
GO:0048255 (mRNA stabilization)
GO:0060213 (positive regulation of nuclear-transcribed mRNA poly(A) tail shortening)
GO:1900153 (positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)
GO:2000623 (negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)
Wikipedia PABPC1

Target Cross References - Protein

Human Protein Atlas ENSG00000070756
IntAct P11940
Open Targets ENSG00000070756
PharmGKB PA32880
Reactome R-HSA-156827 (L13a-mediated translational silencing of Ceruloplasmin expression.)
R-HSA-429947 (Deadenylation of mRNA.)
R-HSA-450408 (AUF1 (hnRNP D0) binds and destabilizes mRNA.)
R-HSA-72649 (Translation initiation complex formation.)
R-HSA-975956 (Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).)
R-HSA-975957 (Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).)
UniProt P11940 Q15097 Q93004

Target Cross References - Domain

InterPro IPR000504 (RRM_dom.)
IPR002004 (PABP_HYD.)
IPR003954 (RRM_dom_euk.)
IPR006515 (PABP_1234.)
IPR012677 (Nucleotide-bd_a/b_plait.)
Pfam PF00076 (RRM_1)
PF00658 (PABP)

Target Cross References - Structure

PDBe 1CVJ 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA
CREDO 1CVJ 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA
spacer
spacer