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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293278
Target Type SINGLE PROTEIN
Preferred Name Geminin
Synonyms GMNN | Geminin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Geminin SINGLE PROTEIN O75496

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112312
Ensembl ENSG00000112312
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0003714 (transcription corepressor activity)
GO:0005515 (protein binding)
GO:0042826 (histone deacetylase binding)
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0006275 (regulation of DNA replication)
GO:0006461 (protein complex assembly)
GO:0007049 (cell cycle)
GO:0008156 (negative regulation of DNA replication)
GO:0009887 (organ morphogenesis)
GO:0045786 (negative regulation of cell cycle)
GO:0045892 (negative regulation of transcription, DNA-templated)
Wikipedia Geminin

Target Cross References - Protein

Human Protein Atlas ENSG00000112312
IntAct O75496
Open Targets ENSG00000112312
PharmGKB PA38455
Reactome R-HSA-68827 (CDT1 association with the CDC6:ORC:origin complex.)
R-HSA-69298 (Association of licensing factors with the pre-replicative complex.)
R-HSA-69300 (Removal of licensing factors from origins.)
UniProt B3KMM8 O75496 Q9H1Z1

Target Cross References - Domain

InterPro IPR022786 (Geminin/Multicilin.)
IPR029697 (Geminin.)
Pfam PF07412 (Geminin)

Target Cross References - Structure

PDBe 1T6F 1UII 2WVR 4BRY
CREDO 1T6F 1UII 2WVR 4BRY
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