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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293277
Target Type SINGLE PROTEIN
Preferred Name Niemann-Pick C1 protein
Synonyms NPC1 | Niemann-Pick C1 protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Niemann-Pick C1 protein SINGLE PROTEIN O15118

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141458
Ensembl ENSG00000141458
GO Cellular Component GO:0005635 (nuclear envelope)
GO:0005765 (lysosomal membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005887 (integral to plasma membrane)
GO:0031902 (late endosome membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005515 (protein binding)
GO:0008158 (hedgehog receptor activity)
GO:0015248 (sterol transporter activity)
GO Biological Process GO:0006914 (autophagy)
GO:0007041 (lysosomal transport)
GO:0008206 (bile acid metabolic process)
GO:0033344 (cholesterol efflux)
GO:0042632 (cholesterol homeostasis)
Wikipedia NPC1

Target Cross References - Protein

CGD Niemann-Pick disease, type C1; Niemann-Pick disease, type D
Human Protein Atlas ENSG00000141458
PharmGKB PA31698
UniProt O15118 Q9P130

Target Cross References - Domain

InterPro IPR000731 (SSD.)
IPR003392 (Patched.)
IPR004765 (NP_C_type.)
Pfam PF02460 (Patched)

Target Cross References - Structure

PDBe 3GKH 3GKI 3GKJ
CREDO 3GKH 3GKI 3GKJ
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