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Target Report Card

Target Name and Classification

Target ID CHEMBL1293266
Preferred Name Nucleotide-binding oligomerization domain-containing protein 2
Synonyms CARD15 | Caspase recruitment domain-containing protein 15 | IBD1 | Inflammatory bowel disease protein 1 | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Nucleotide-binding oligomerization domain-containing protein 2 SINGLE PROTEIN Q9HC29

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107354 MIFAMURTIDE Nucleotide-binding oligomerization domain-containing protein 2 other 4 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167207
Ensembl ENSG00000167207
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0008180 (COP9 signalosome)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016323 (basolateral plasma membrane)
GO:0031982 (vesicle)
GO:0032991 (macromolecular complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003779 (actin binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0030544 (Hsp70 protein binding)
GO:0032500 (muramyl dipeptide binding)
GO:0042834 (peptidoglycan binding)
GO:0050700 (CARD domain binding)
GO:0051879 (Hsp90 protein binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0002367 (cytokine production involved in immune response)
GO:0002374 (cytokine secretion involved in immune response)
GO:0002376 (immune system process)
GO:0002606 (positive regulation of dendritic cell antigen processing and presentation)
GO:0002732 (positive regulation of dendritic cell cytokine production)
GO:0002830 (positive regulation of type 2 immune response)
GO:0006952 (defense response)
GO:0007254 (JNK cascade)
GO:0007584 (response to nutrient)
GO:0008284 (positive regulation of cell proliferation)
GO:0009595 (detection of biotic stimulus)
GO:0016045 (detection of bacterium)
GO:0016579 (protein deubiquitination)
GO:0030277 (maintenance of gastrointestinal epithelium)
GO:0032495 (response to muramyl dipeptide)
GO:0032498 (detection of muramyl dipeptide)
GO:0032731 (positive regulation of interleukin-1 beta production)
GO:0032733 (positive regulation of interleukin-10 production)
GO:0032740 (positive regulation of interleukin-17 production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032874 (positive regulation of stress-activated MAPK cascade)
GO:0035556 (intracellular signal transduction)
GO:0042742 (defense response to bacterium)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045087 (innate immune response)
GO:0045747 (positive regulation of Notch signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046330 (positive regulation of JNK cascade)
GO:0046645 (positive regulation of gamma-delta T cell activation)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050718 (positive regulation of interleukin-1 beta secretion)
GO:0050727 (regulation of inflammatory response)
GO:0050871 (positive regulation of B cell activation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051259 (protein oligomerization)
GO:0051353 (positive regulation of oxidoreductase activity)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0060585 (positive regulation of prostaglandin-endoperoxide synthase activity)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:0070431 (nucleotide-binding oligomerization domain containing 2 signaling pathway)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0071224 (cellular response to peptidoglycan)
GO:0071225 (cellular response to muramyl dipeptide)
GO:0071407 (cellular response to organic cyclic compound)
GO:1900017 (positive regulation of cytokine production involved in inflammatory response)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
GO:1902523 (positive regulation of protein K63-linked ubiquitination)
GO:2000110 (negative regulation of macrophage apoptotic process)
GO:2000363 (positive regulation of prostaglandin-E synthase activity)
Wikipedia NOD2

Target Cross References - Protein

CGD Blau syndrome; Sarcoidosis, early-onset
Human Protein Atlas ENSG00000167207
IntAct Q9HC29
Guide to Pharmacology 1763
Open Targets ENSG00000167207
PharmGKB PA26074
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-5689896 (Ovarian tumor domain proteases.)
R-HSA-9020702 (Interleukin-1 signaling.)
UniProt E2JEQ6 Q96RH5 Q96RH6 Q96RH8 Q9HC29

Target Cross References - Domain

InterPro IPR001315 (CARD.)
IPR001611 (Leu-rich_rpt.)
IPR007111 (NACHT_NTPase.)
IPR011029 (DEATH-like_dom_sf.)
IPR027417 (P-loop_NTPase.)
IPR032675 (LRR_dom_sf.)
Pfam PF00619 (CARD)
PF13516 (LRR_6)