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Target Report Card

Target Name and Classification

Target ID CHEMBL1293258
Preferred Name Mothers against decapentaplegic homolog 3
Synonyms JV15-2 | MAD homolog 3 | MADH3 | Mad3 | Mothers against DPP homolog 3 | Mothers against decapentaplegic homolog 3 | SMAD 3 | SMAD family member 3 | SMAD3 | Smad3 | hMAD-3 | hSMAD3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Mothers against decapentaplegic homolog 3 SINGLE PROTEIN P84022

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166949
Ensembl ENSG00000166949
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005637 (nuclear inner membrane)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0043234 (protein complex)
GO:0043235 (receptor complex)
GO:0071141 (SMAD protein complex)
GO:0071144 (SMAD2-SMAD3 protein complex)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000983 (transcription factor activity, RNA polymerase II core promoter sequence-specific)
GO:0000987 (core promoter proximal region sequence-specific DNA binding)
GO:0000988 (transcription factor activity, protein binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005160 (transforming growth factor beta receptor binding)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0019902 (phosphatase binding)
GO:0030618 (transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity)
GO:0031490 (chromatin DNA binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0035326 (enhancer binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043130 (ubiquitin binding)
GO:0043425 (bHLH transcription factor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046332 (SMAD binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0070410 (co-SMAD binding)
GO:0070412 (R-SMAD binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001501 (skeletal system development)
GO:0001649 (osteoblast differentiation)
GO:0001657 (ureteric bud development)
GO:0001666 (response to hypoxia)
GO:0001701 (in utero embryonic development)
GO:0001707 (mesoderm formation)
GO:0001756 (somitogenesis)
GO:0001889 (liver development)
GO:0001947 (heart looping)
GO:0002076 (osteoblast development)
GO:0002520 (immune system development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006810 (transport)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006955 (immune response)
GO:0007050 (cell cycle arrest)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007183 (SMAD protein complex assembly)
GO:0007369 (gastrulation)
GO:0007492 (endoderm development)
GO:0008285 (negative regulation of cell proliferation)
GO:0009880 (embryonic pattern specification)
GO:0010628 (positive regulation of gene expression)
GO:0010694 (positive regulation of alkaline phosphatase activity)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0016202 (regulation of striated muscle tissue development)
GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway)
GO:0019049 (evasion or tolerance of host defenses by virus)
GO:0023019 (signal transduction involved in regulation of gene expression)
GO:0030308 (negative regulation of cell growth)
GO:0030335 (positive regulation of cell migration)
GO:0030501 (positive regulation of bone mineralization)
GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
GO:0030878 (thyroid gland development)
GO:0031053 (primary miRNA processing)
GO:0032332 (positive regulation of chondrocyte differentiation)
GO:0032731 (positive regulation of interleukin-1 beta production)
GO:0032909 (regulation of transforming growth factor beta2 production)
GO:0032916 (positive regulation of transforming growth factor beta3 production)
GO:0032924 (activin receptor signaling pathway)
GO:0033689 (negative regulation of osteoblast proliferation)
GO:0038092 (nodal signaling pathway)
GO:0042060 (wound healing)
GO:0042110 (T cell activation)
GO:0042993 (positive regulation of transcription factor import into nucleus)
GO:0043066 (negative regulation of apoptotic process)
GO:0045216 (cell-cell junction organization)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045930 (negative regulation of mitotic cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048340 (paraxial mesoderm morphogenesis)
GO:0048589 (developmental growth)
GO:0048617 (embryonic foregut morphogenesis)
GO:0048701 (embryonic cranial skeleton morphogenesis)
GO:0050678 (regulation of epithelial cell proliferation)
GO:0050728 (negative regulation of inflammatory response)
GO:0050776 (regulation of immune response)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051098 (regulation of binding)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0051894 (positive regulation of focal adhesion assembly)
GO:0060039 (pericardium development)
GO:0060290 (transdifferentiation)
GO:0060395 (SMAD protein signal transduction)
GO:0061045 (negative regulation of wound healing)
GO:0070306 (lens fiber cell differentiation)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097296 (activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO:1901203 (positive regulation of extracellular matrix assembly)
Wikipedia Mothers_against_decapentaplegic_homolog_3

Target Cross References - Protein

CGD Aneurysms-osteoarthritis syndrome; Loeys-Dietz syndrome, type 1C
Human Protein Atlas ENSG00000166949
IntAct P84022
Open Targets ENSG00000166949
PharmGKB PA30526
Reactome R-HSA-1181150 (Signaling by NODAL.)
R-HSA-1502540 (Signaling by Activin.)
R-HSA-2173788 (Downregulation of TGF-beta receptor signaling.)
R-HSA-2173789 (TGF-beta receptor signaling activates SMADs.)
R-HSA-2173795 (Downregulation of SMAD2/3:SMAD4 transcriptional activity.)
R-HSA-2173796 (SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.)
R-HSA-3304356 (SMAD2/3 Phosphorylation Motif Mutants in Cancer.)
R-HSA-3311021 (SMAD4 MH2 Domain Mutants in Cancer.)
R-HSA-3315487 (SMAD2/3 MH2 Domain Mutants in Cancer.)
R-HSA-3656532 (TGFBR1 KD Mutants in Cancer.)
R-HSA-5689880 (Ub-specific processing proteases.)
UniProt A8K4B6 B7Z4Z5 B7Z6M9 B7Z9Q2 F5H383 O09064 O09144 O14510 O35273 P84022 Q92940 Q93002 Q9GKR4

Target Cross References - Domain

InterPro IPR001132 (SMAD_dom_Dwarfin-type.)
IPR003619 (MAD_homology1_Dwarfin-type.)
IPR008984 (SMAD_FHA_domain.)
IPR013019 (MAD_homology_MH1.)
IPR013790 (Dwarfin.)
IPR017855 (SMAD_dom-like.)
Pfam PF03165 (MH1)
PF03166 (MH2)

Target Cross References - Structure