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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293258
Target Type SINGLE PROTEIN
Preferred Name Mothers against decapentaplegic homolog 3
Synonyms JV15-2 | MAD homolog 3 | MADH3 | Mad3 | Mothers against DPP homolog 3 | Mothers against decapentaplegic homolog 3 | SMAD 3 | SMAD family member 3 | SMAD3 | Smad3 | hMAD-3 | hSMAD3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Mothers against decapentaplegic homolog 3 SINGLE PROTEIN P84022

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166949
Ensembl ENSG00000166949
GO Cellular Component GO:0005637 (nuclear inner membrane)
GO:0005829 (cytosol)
GO:0043235 (receptor complex)
GO Molecular Function GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0005160 (transforming growth factor beta receptor binding)
GO:0008013 (beta-catenin binding)
GO:0010843 (promoter binding)
GO:0019901 (protein kinase binding)
GO:0030618 (transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0070410 (co-SMAD binding)
GO:0070412 (R-SMAD binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001666 (response to hypoxia)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0006810 (transport)
GO:0006917 (induction of apoptosis)
GO:0006919 (activation of caspase activity)
GO:0006955 (immune response)
GO:0007050 (cell cycle arrest)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007183 (SMAD protein complex assembly)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway)
GO:0019049 (evasion of host defenses by virus)
GO:0030308 (negative regulation of cell growth)
GO:0031053 (primary microRNA processing)
GO:0032909 (regulation of transforming growth factor-beta2 production)
GO:0035413 (positive regulation of catenin import into nucleus)
GO:0042060 (wound healing)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042993 (positive regulation of transcription factor import into nucleus)
GO:0045216 (cell-cell junction organization)
GO:0045930 (negative regulation of mitotic cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0050821 (protein stabilization)
GO:0090263 (positive regulation of canonical Wnt receptor signaling pathway)
Wikipedia Mothers_against_decapentaplegic_homolog_3

Target Cross References - Protein

CGD Aneurysms-osteoarthritis syndrome; Loeys-Dietz syndrome, type 1C
Human Protein Atlas ENSG00000166949
IntAct P84022
PharmGKB PA30526
Reactome REACT_6844 (Signaling by TGF beta.)
UniProt A8K4B6 O09064 O09144 O14510 O35273 P84022 Q92940 Q93002 Q9GKR4

Target Cross References - Domain

InterPro IPR001132 (SMAD_dom_Dwarfin-type.)
IPR003619 (MAD_homology1_Dwarfin-type.)
IPR008984 (SMAD_FHA_domain.)
IPR013019 (MAD_homology_MH1.)
IPR013790 (Dwarfin.)
IPR017855 (SMAD_dom-like.)
Pfam PF03165 (MH1)
PF03166 (MH2)

Target Cross References - Structure

PDBe 1MHD 1MJS 1MK2 1OZJ 1U7F
CREDO 1MHD 1MJS 1MK2 1OZJ 1U7F
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