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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293256
Target Type SINGLE PROTEIN
Preferred Name Thrombopoietin
Synonyms C-mpl ligand | MGDF | MGDF | ML | Megakaryocyte colony-stimulating factor | Megakaryocyte growth and development factor | Myeloproliferative leukemia virus oncogene ligand | THPO | Thrombopoietin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Thrombopoietin SINGLE PROTEIN P40225

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000090534
Ensembl ENSG00000090534
GO Cellular Component GO:0005615 (extracellular space)
GO Molecular Function GO:0005125 (cytokine activity)
GO:0005179 (hormone activity)
GO:0008083 (growth factor activity)
GO Biological Process GO:0008283 (cell proliferation)
GO:0030168 (platelet activation)
Wikipedia Thrombopoietin

Target Cross References - Protein

CGD Thrombocythemia 1
Human Protein Atlas ENSG00000090534
PharmGKB PA36506
Reactome REACT_604 (Hemostasis.)
UniProt A1L3Y0 B7ZLR8 B9EGA8 P40225 Q13020 Q15790 Q15791 Q15792

Target Cross References - Domain

InterPro IPR001323 (EPO_TPO.)
IPR003978 (Thrombopoeitin.)
IPR009079 (4_helix_cytokine-like_core.)
IPR012351 (4_helix_cytokine_core.)
IPR019767 (EPO/TPO_CS.)
Pfam PF00758 (EPO_TPO)

Target Cross References - Structure

PDBe 1V7M 1V7N
CREDO 1V7M 1V7N
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