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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293236
Target Type SINGLE PROTEIN
Preferred Name ATP-dependent DNA helicase Q1
Synonyms ATP-dependent DNA helicase Q1 | DNA helicase, RecQ-like type 1 | DNA-dependent ATPase Q1 | RECQ1 | RECQL | RECQL1 | RecQ protein-like 1 | RecQ1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
ATP-dependent DNA helicase Q1 SINGLE PROTEIN P46063

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000004700
Ensembl ENSG00000004700
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003678 (DNA helicase activity)
GO:0004003 (ATP-dependent DNA helicase activity)
GO:0004386 (helicase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008026 (ATP-dependent helicase activity)
GO:0009378 (four-way junction helicase activity)
GO:0016787 (hydrolase activity)
GO:0036310 (annealing helicase activity)
GO:0043140 (ATP-dependent 3'-5' DNA helicase activity)
GO Biological Process GO:0000724 (double-strand break repair via homologous recombination)
GO:0000733 (DNA strand renaturation)
GO:0006281 (DNA repair)
GO:0006310 (DNA recombination)
GO:0032508 (DNA duplex unwinding)
Wikipedia RECQL

Target Cross References - Protein

Human Protein Atlas ENSG00000004700
IntAct P46063
Open Targets ENSG00000004700
PharmGKB PA34315
UniProt A8K6G2 P46063

Target Cross References - Domain

InterPro IPR001650 (Helicase_C.)
IPR004589 (DNA_helicase_ATP-dep_RecQ.)
IPR011545 (DEAD/DEAH_box_helicase_dom.)
IPR011991 (WHTH_DNA-bd_dom.)
IPR014001 (Helicase_ATP-bd.)
IPR027417 (P-loop_NTPase.)
IPR032284 (RecQ_Zn-bd.)
Pfam PF00270 (DEAD)
PF00271 (Helicase_C)
PF16124 (RecQ_Zn_bind)

Target Cross References - Structure

PDBe 2V1X 2WWY 4U7D
CREDO 2V1X 2WWY 4U7D
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