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Target Report Card

Target Name and Classification

Target ID CHEMBL1293235
Preferred Name Prelamin-A/C
Synonyms 70 kDa lamin | LMN1 | LMNA | Lamin-A/C | Prelamin-A/C | Renal carcinoma antigen NY-REN-32
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Prelamin-A/C SINGLE PROTEIN P02545

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160789
Ensembl ENSG00000160789
GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005638 (lamin filament)
GO:0005652 (nuclear lamina)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0005882 (intermediate filament)
GO:0016607 (nuclear speck)
GO:0031965 (nuclear membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005198 (structural molecule activity)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006997 (nucleus organization)
GO:0006998 (nuclear envelope organization)
GO:0007077 (mitotic nuclear envelope disassembly)
GO:0007084 (mitotic nuclear envelope reassembly)
GO:0007517 (muscle organ development)
GO:0008285 (negative regulation of cell proliferation)
GO:0010628 (positive regulation of gene expression)
GO:0030334 (regulation of cell migration)
GO:0030951 (establishment or maintenance of microtubule cytoskeleton polarity)
GO:0032204 (regulation of telomere maintenance)
GO:0034504 (protein localization to nucleus)
GO:0034613 (cellular protein localization)
GO:0036498 (IRE1-mediated unfolded protein response)
GO:0055015 (ventricular cardiac muscle cell development)
GO:0071456 (cellular response to hypoxia)
GO:0072201 (negative regulation of mesenchymal cell proliferation)
GO:0090201 (negative regulation of release of cytochrome c from mitochondria)
GO:0090343 (positive regulation of cell aging)
GO:1900180 (regulation of protein localization to nucleus)
GO:1903243 (negative regulation of cardiac muscle hypertrophy in response to stress)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia LMNA

Target Cross References - Protein

CGD Cardiomyopathy, dilated, 1A; Heart-hand syndrome, Slovenian type; Emery-Dreiffus muscular dystrophy, autosomal dominant; Emery-Dreiffus muscular dystrophy, autosomal recessive; Muscular dystrophy, congenital, LMNA-related; Limb-girdle muscular dystrophy type 1B; Malouf syndrome; Lipodystrophy, familial partial, 2 (Dunnigan type)
Human Protein Atlas ENSG00000160789
IntAct P02545
Open Targets ENSG00000160789
PharmGKB PA231
Reactome R-HSA-1221632 (Meiotic synapsis.)
R-HSA-2993913 (Clearance of Nuclear Envelope Membranes from Chromatin.)
R-HSA-2995383 (Initiation of Nuclear Envelope Reformation.)
R-HSA-352238 (Breakdown of the nuclear lamina.)
R-HSA-381038 (XBP1(S) activates chaperone genes.)
R-HSA-4419969 (Depolymerisation of the Nuclear Lamina.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
UniProt B4DI32 D3DVB0 D6RAQ3 E7EUI9 P02545 P02546 Q5I6Y4 Q5I6Y6 Q5TCJ2 Q5TCJ3 Q6UYC3 Q969I8 Q96JA2

Target Cross References - Domain

InterPro IPR001322 (Lamin_tail_dom.)
IPR001664 (IF.)
IPR018039 (Intermediate_filament_CS.)
IPR036415 (Lamin_tail_dom_sf.)
Pfam PF00038 (Filament)
PF00932 (LTD)

Target Cross References - Structure

PDBe 1IFR 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B