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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293232
Target Type SINGLE PROTEIN
Preferred Name Survival motor neuron protein
Synonyms Component of gems 1 | Gemin-1 | SMN | SMN2 | SMNT | Survival motor neuron protein | andSMNC
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > reader > methyl-lysine/arginine binding protein > tudor domain

Target Components

Component Description Relationship Accession
Survival motor neuron protein SINGLE PROTEIN Q16637

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172062 ENSG00000205571 ENSG00000273772 ENSG00000275349 ENSG00000277773
Ensembl ENSG00000172062 ENSG00000205571 ENSG00000273772 ENSG00000275349 ENSG00000277773
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0015030 (Cajal body)
GO:0030018 (Z disc)
GO:0032797 (SMN complex)
GO:0034719 (SMN-Sm protein complex)
GO:0036464 (cytoplasmic ribonucleoprotein granule)
GO:0043005 (neuron projection)
GO:0043204 (perikaryon)
GO:0097504 (Gemini of coiled bodies)
GO Molecular Function GO:0003723 (RNA binding)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0000245 (spliceosomal complex assembly)
GO:0000387 (spliceosomal snRNP assembly)
GO:0006353 (DNA-templated transcription, termination)
GO:0006397 (mRNA processing)
GO:0007399 (nervous system development)
GO:0008380 (RNA splicing)
GO:0051170 (nuclear import)
Wikipedia SMN1

Target Cross References - Protein

CGD Spinal muscular atrophy, type I; Spinal muscular atrophy, type II; Spinal muscular atrophy, type III; Spinal muscular atrophy, type IV
Human Protein Atlas ENSG00000172062 ENSG00000205571 ENSG00000273772 ENSG00000275349 ENSG00000277773
IntAct Q16637
Open Targets ENSG00000172062 ENSG00000205571 ENSG00000273772 ENSG00000275349 ENSG00000277773
PharmGKB PA35967
Reactome R-HSA-191859 (snRNP Assembly.)
UniProt A8K0V4 Q13119 Q16637 Q549U5 Q96J51

Target Cross References - Domain

InterPro IPR002999 (Tudor.)
IPR010304 (Survival_motor_neuron.)
Pfam PF06003 (SMN)

Target Cross References - Structure

PDBe 1MHN 3S6N 4GLI 4NL6 4NL7 4QQ6
CREDO 1MHN 3S6N 4GLI 4NL6 4NL7 4QQ6
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