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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293230
Target Type SINGLE PROTEIN
Preferred Name Polypyrimidine tract-binding protein 1
Synonyms 57 kDa RNA-binding protein PPTB-1 | Heterogeneous nuclear ribonucleoprotein I | PTB | PTB | PTBP1 | Polypyrimidine tract-binding protein 1 | hnRNP I
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Polypyrimidine tract-binding protein 1 SINGLE PROTEIN P26599

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000011304
Ensembl ENSG00000011304
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003676 (nucleic acid binding)
GO:0003723 (RNA binding)
GO:0005515 (protein binding)
GO:0008187 (poly-pyrimidine tract binding)
GO:0036002 (pre-mRNA binding)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0000381 (regulation of alternative mRNA splicing, via spliceosome)
GO:0000398 (mRNA splicing, via spliceosome)
GO:0006397 (mRNA processing)
GO:0008380 (RNA splicing)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0010467 (gene expression)
GO:0033119 (negative regulation of RNA splicing)
GO:0048025 (negative regulation of mRNA splicing, via spliceosome)
GO:0051148 (negative regulation of muscle cell differentiation)
GO:0075522 (IRES-dependent viral translational initiation)
Wikipedia PTBP1

Target Cross References - Protein

Human Protein Atlas ENSG00000011304
IntAct P26599
Open Targets ENSG00000011304
PharmGKB PA33934
Reactome R-HSA-6803529 (FGFR2 alternative splicing.)
R-HSA-72163 (mRNA Splicing - Major Pathway.)
R-HSA-72203 (Processing of Capped Intron-Containing Pre-mRNA.)
UniProt P26599 Q9BUQ0

Target Cross References - Domain

InterPro IPR000504 (RRM_dom.)
IPR006536 (HnRNP-L/PTB.)
IPR012677 (Nucleotide-bd_a/b_plait.)
Pfam PF00076 (RRM_1)

Target Cross References - Structure

PDBe 3ZZY 3ZZZ
CREDO 3ZZY 3ZZZ
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