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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293229
Target Type SINGLE PROTEIN
Preferred Name Nuclear receptor subfamily 4 group A member 1
Synonyms Early response protein NAK1 | GFRP1 | HMR | NAK1 | NR4A1 | Nuclear hormone receptor NUR/77 | Nuclear receptor subfamily 4 group A member 1 | Nur77 | Orphan nuclear receptor HMR | Orphan nuclear receptor TR3 | ST-59 | Testicular receptor 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 4 > nuclear hormone receptor subfamily 4 group a > nuclear hormone receptor subfamily 4 group a member 1

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 4 group A member 1 SINGLE PROTEIN P22736

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123358
Ensembl ENSG00000123358
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002042 (cell migration involved in sprouting angiogenesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0030522 (intracellular receptor signaling pathway)
GO:0035767 (endothelial cell chemotaxis)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0044344 (cellular response to fibroblast growth factor stimulus)
GO:0045444 (fat cell differentiation)
GO:0045786 (negative regulation of cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0061469 (regulation of type B pancreatic cell proliferation)
GO:0071376 (cellular response to corticotropin-releasing hormone stimulus)
Wikipedia Nerve_Growth_factor_IB

Target Cross References - Protein

Human Protein Atlas ENSG00000123358
IntAct P22736
Open Targets ENSG00000123358
PharmGKB PA31761
Pharos P22736 (Tchem)
Reactome R-HSA-198693 (AKT phosphorylates targets in the nucleus.)
R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
UniProt B4DML7 P22736 Q15627 Q53Y00 Q6IBU8

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003070 (Nuc_orph_rcpt.)
IPR003071 (Nuc_orp_HMR_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG
CREDO 2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG
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