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Target Report Card

Target Name and Classification

Target ID CHEMBL1293224
Preferred Name Microtubule-associated protein tau
Synonyms MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Microtubule-associated protein tau SINGLE PROTEIN P10636

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186868 ENSG00000276155 ENSG00000277956
Ensembl ENSG00000186868 ENSG00000276155 ENSG00000277956
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005875 (microtubule associated complex)
GO:0005886 (plasma membrane)
GO:0005930 (axoneme)
GO:0014069 (postsynaptic density)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0034399 (nuclear periphery)
GO:0036464 (cytoplasmic ribonucleoprotein granule)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0044297 (cell body)
GO:0045298 (tubulin complex)
GO:0097418 (neurofibrillary tangle)
GO Molecular Function GO:0005200 (structural constituent of cytoskeleton)
GO:0005515 (protein binding)
GO:0008017 (microtubule binding)
GO:0015631 (tubulin binding)
GO:0017124 (SH3 domain binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0032403 (protein complex binding)
GO:0034185 (apolipoprotein binding)
GO:0051721 (protein phosphatase 2A binding)
GO:0071813 (lipoprotein particle binding)
GO Biological Process GO:0000226 (microtubule cytoskeleton organization)
GO:0001764 (neuron migration)
GO:0006915 (apoptotic process)
GO:0007409 (axonogenesis)
GO:0007420 (brain development)
GO:0007565 (female pregnancy)
GO:0007584 (response to nutrient)
GO:0007628 (adult walking behavior)
GO:0008088 (axo-dendritic transport)
GO:0008631 (intrinsic apoptotic signaling pathway in response to oxidative stress)
GO:0010033 (response to organic substance)
GO:0010506 (regulation of autophagy)
GO:0031113 (regulation of microtubule polymerization)
GO:0031116 (positive regulation of microtubule polymerization)
GO:0032387 (negative regulation of intracellular transport)
GO:0045773 (positive regulation of axon extension)
GO:0047497 (mitochondrion transport along microtubule)
GO:0048675 (axon extension)
GO:0048699 (generation of neurons)
GO:0060632 (regulation of microtubule-based movement)
Wikipedia Tau_protein

Target Cross References - Protein

canSAR P10636
CGD Supranuclear palsy, progressive; Frontotemporal dementia; Parkinson-dementia sydnrome; Pick disease
Human Protein Atlas ENSG00000186868 ENSG00000276155 ENSG00000277956
IntAct P10636
Open Targets ENSG00000186868 ENSG00000276155 ENSG00000277956
PharmGKB PA238
Reactome R-HSA-264870 (Caspase-mediated cleavage of cytoskeletal proteins.)
UniProt P10636 P18518 Q14799 Q15549 Q15550 Q15551 Q1RMF6 Q53YB1 Q5CZI7 Q5XWF0 Q6QT54 Q9UDJ3 Q9UMH0 Q9UQ96

Target Cross References - Domain

InterPro IPR001084 (MAP_tubulin-bd_rpt.)
IPR002955 (Tau.)
Pfam PF00418 (Tubulin-binding)

Target Cross References - Structure

PDBe 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3
CREDO 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3