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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293222
Target Type SINGLE PROTEIN
Preferred Name Nucleotide-binding oligomerization domain-containing protein 1
Synonyms CARD4 | Caspase recruitment domain-containing protein 4 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Nucleotide-binding oligomerization domain-containing protein 1 SINGLE PROTEIN Q9Y239

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106100
Ensembl ENSG00000106100
GO Cellular Component GO:0005829 (cytosol)
GO:0016323 (basolateral plasma membrane)
GO Molecular Function GO:0005524 (ATP binding)
GO:0008656 (caspase activator activity)
GO:0042803 (protein homodimerization activity)
GO:0042834 (peptidoglycan binding)
GO:0050700 (CARD domain binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0002606 (positive regulation of dendritic cell antigen processing and presentation)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0002756 (MyD88-independent toll-like receptor signaling pathway)
GO:0006917 (induction of apoptosis)
GO:0006954 (inflammatory response)
GO:0007254 (JNK cascade)
GO:0008063 (Toll signaling pathway)
GO:0016045 (detection of bacterium)
GO:0034130 (toll-like receptor 1 signaling pathway)
GO:0034134 (toll-like receptor 2 signaling pathway)
GO:0034138 (toll-like receptor 3 signaling pathway)
GO:0034142 (toll-like receptor 4 signaling pathway)
GO:0042228 (interleukin-8 biosynthetic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0045087 (innate immune response)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051259 (protein oligomerization)
GO:0051403 (stress-activated MAPK cascade)
Wikipedia NOD1

Target Cross References - Protein

Human Protein Atlas ENSG00000106100
IntAct Q9Y239
Guide to Pharmacology 1762 (NLRC1)
PharmGKB PA162398098
Reactome REACT_6900 (Signaling in Immune system.)
UniProt Q549U4 Q8IWF5 Q9Y239

Target Cross References - Domain

InterPro IPR001315 (CARD.)
IPR007111 (NACHT_NTPase.)
IPR011029 (DEATH-like.)
Pfam PF00619 (CARD)

Target Cross References - Structure

PDBe 2NSN 2NZ7
CREDO 2NSN 2NZ7
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