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Target Report Card

Target Name and Classification

Target ID CHEMBL1293222
Target Type SINGLE PROTEIN
Preferred Name Nucleotide-binding oligomerization domain-containing protein 1
Synonyms CARD4 | Caspase recruitment domain-containing protein 4 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Nucleotide-binding oligomerization domain-containing protein 1 SINGLE PROTEIN Q9Y239

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106100
Ensembl ENSG00000106100
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008656 (cysteine-type endopeptidase activator activity involved in apoptotic process)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0042834 (peptidoglycan binding)
GO:0050700 (CARD domain binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0002376 (immune system process)
GO:0002606 (positive regulation of dendritic cell antigen processing and presentation)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006952 (defense response)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007254 (JNK cascade)
GO:0009595 (detection of biotic stimulus)
GO:0010942 (positive regulation of cell death)
GO:0016045 (detection of bacterium)
GO:0032731 (positive regulation of interleukin-1 beta production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032760 (positive regulation of tumor necrosis factor production)
GO:0032874 (positive regulation of stress-activated MAPK cascade)
GO:0035556 (intracellular signal transduction)
GO:0042228 (interleukin-8 biosynthetic process)
GO:0042742 (defense response to bacterium)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0045087 (innate immune response)
GO:0046330 (positive regulation of JNK cascade)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051259 (protein oligomerization)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
GO:0071225 (cellular response to muramyl dipeptide)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
GO:1904417 (positive regulation of xenophagy)
Wikipedia NOD1

Target Cross References - Protein

Human Protein Atlas ENSG00000106100
IntAct Q9Y239
Guide to Pharmacology 1762
Open Targets ENSG00000106100
PharmGKB PA162398098
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-446652 (Interleukin-1 signaling.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
UniProt B4DTU3 Q549U4 Q8IWF5 Q9Y239

Target Cross References - Domain

InterPro IPR001315 (CARD.)
IPR001611 (Leu-rich_rpt.)
IPR007111 (NACHT_NTPase.)
IPR011029 (DEATH-like_dom.)
IPR032675 (L_dom-like.)
Pfam PF00619 (CARD)
PF13516 (LRR_6)

Target Cross References - Structure

PDBe 2NSN 2NZ7 4E9M 4JQW
CREDO 2NSN 2NZ7 4E9M 4JQW
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