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Target Report Card

Target Name and Classification

Target ID CHEMBL1293193
Target Type SINGLE PROTEIN
Preferred Name Atrial natriuretic factor
Synonyms ANF | ANP | ANP | Atrial natriuretic factor | Atrial natriuretic peptide | CDD | CDD-ANF | CDP | Cardiodilatin | Cardiodilatin-related peptide | NPPA | Natriuretic peptides A | PND | Prepronatriodilatin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Natriuretic peptides A SINGLE PROTEIN P01160

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175206
Ensembl ENSG00000175206
GO Cellular Component GO:0042629 (mast cell granule)
GO:0005615 (extracellular space)
GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005102 (receptor binding)
GO:0071855 (neuropeptide receptor binding)
GO:0005184 (neuropeptide hormone activity)
GO Biological Process GO:0060452 (positive regulation of cardiac muscle contraction)
GO:1903766 (positive regulation of potassium ion export across plasma membrane)
GO:0007218 (neuropeptide signaling pathway)
GO:0010460 (positive regulation of heart rate)
GO:0030308 (negative regulation of cell growth)
GO:0001666 (response to hypoxia)
GO:0007168 (receptor guanylyl cyclase signaling pathway)
GO:0014898 (cardiac muscle hypertrophy in response to stress)
GO:0050880 (regulation of blood vessel size)
GO:0006182 (cGMP biosynthetic process)
GO:0007565 (female pregnancy)
GO:0008217 (regulation of blood pressure)
GO:0010467 (gene expression)
GO:1902261 (positive regulation of delayed rectifier potassium channel activity)
GO:1902514 (regulation of generation of L-type calcium current)
GO:1901841 (regulation of high voltage-gated calcium channel activity)
GO:0003085 (negative regulation of systemic arterial blood pressure)
GO:0032868 (response to insulin)
GO:0035994 (response to muscle stretch)
GO:0044267 (cellular protein metabolic process)
GO:0060372 (regulation of atrial cardiac muscle cell membrane repolarization)
GO:0061049 (cell growth involved in cardiac muscle cell development)
GO:0071260 (cellular response to mechanical stimulus)
GO:1903815 (negative regulation of collecting lymphatic vessel constriction)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
Wikipedia Atrial_natriuretic_peptide

Target Cross References - Protein

CGD Atrial fibrillation, familial, 6
Human Protein Atlas ENSG00000175206
IntAct P01160
PharmGKB PA256
UniProt Q5JZE1 Q13766 P01160

Target Cross References - Domain

InterPro IPR030480 (Natr_peptide_CS.)
IPR002407 (Natriuretic_peptide_atrial.)
IPR000663 (Natr_peptide.)
Pfam PF00212 (ANP)

Target Cross References - Structure

PDBe 3N57 1YK0
CREDO 3N57 1YK0
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