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Target Report Card

Target Name and Classification

Target ID CHEMBL1293193
Preferred Name Atrial natriuretic factor
Synonyms ANF | ANP | ANP | Atrial natriuretic factor | Atrial natriuretic peptide | CDD | CDD-ANF | CDP | Cardiodilatin | Cardiodilatin-related peptide | NPPA | Natriuretic peptides A | PND | Prepronatriodilatin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Natriuretic peptides A SINGLE PROTEIN P01160

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175206
Ensembl ENSG00000175206
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0031012 (extracellular matrix)
GO:0032991 (macromolecular complex)
GO:0042629 (mast cell granule)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005179 (hormone activity)
GO:0005184 (neuropeptide hormone activity)
GO:0005515 (protein binding)
GO:0051427 (hormone receptor binding)
GO:0051428 (peptide hormone receptor binding)
GO:0071855 (neuropeptide receptor binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0003085 (negative regulation of systemic arterial blood pressure)
GO:0006182 (cGMP biosynthetic process)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006457 (protein folding)
GO:0007168 (receptor guanylyl cyclase signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007565 (female pregnancy)
GO:0008217 (regulation of blood pressure)
GO:0010460 (positive regulation of heart rate)
GO:0010469 (regulation of receptor activity)
GO:0014898 (cardiac muscle hypertrophy in response to stress)
GO:0030308 (negative regulation of cell growth)
GO:0032868 (response to insulin)
GO:0035994 (response to muscle stretch)
GO:0044267 (cellular protein metabolic process)
GO:0050880 (regulation of blood vessel size)
GO:0060372 (regulation of atrial cardiac muscle cell membrane repolarization)
GO:0060452 (positive regulation of cardiac muscle contraction)
GO:0061049 (cell growth involved in cardiac muscle cell development)
GO:0071260 (cellular response to mechanical stimulus)
GO:1901841 (regulation of high voltage-gated calcium channel activity)
GO:1902261 (positive regulation of delayed rectifier potassium channel activity)
GO:1902514 (regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)
GO:1903595 (positive regulation of histamine secretion by mast cell)
GO:1903766 (positive regulation of potassium ion export across plasma membrane)
GO:1903779 (regulation of cardiac conduction)
GO:1903815 (negative regulation of collecting lymphatic vessel constriction)
Wikipedia Atrial_natriuretic_peptide

Target Cross References - Protein

CGD Atrial fibrillation, familial, 6
Human Protein Atlas ENSG00000175206
IntAct P01160
Open Targets ENSG00000175206
PharmGKB PA256
Reactome R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-5578768 (Physiological factors.)
R-HSA-977225 (Amyloid fiber formation.)
UniProt P01160 Q13766 Q5JZE1

Target Cross References - Domain

InterPro IPR000663 (Natr_peptide.)
IPR002407 (Natriuretic_peptide_atrial.)
IPR030480 (Natr_peptide_CS.)
Pfam PF00212 (ANP)

Target Cross References - Structure

PDBe 1YK0 3N57