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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293191
Target Type SINGLE PROTEIN
Preferred Name Transcriptional regulator ERG
Synonyms ERG | Transcriptional regulator ERG | Transforming protein ERG
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Transcriptional regulator ERG SINGLE PROTEIN P11308

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000157554
Ensembl ENSG00000157554
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0030529 (intracellular ribonucleoprotein complex)
GO Molecular Function GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0003197 (endocardial cushion development)
GO:0003199 (endocardial cushion to mesenchymal transition involved in heart valve formation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0008283 (cell proliferation)
GO:0016477 (cell migration)
GO:0030154 (cell differentiation)
GO:2000504 (positive regulation of blood vessel remodeling)
Wikipedia ERG_(gene)

Target Cross References - Protein

canSAR P11308
Human Protein Atlas ENSG00000157554
IntAct P11308
Open Targets ENSG00000157554
PharmGKB PA27858
UniProt B4DTW5 B4E0T4 P11308 Q16113 Q6XXX4 Q6XXX5 Q8IXK9

Target Cross References - Domain

InterPro IPR000418 (Ets_dom.)
IPR003118 (Pointed_dom.)
IPR011991 (WHTH_DNA-bd_dom.)
IPR013761 (SAM/pointed.)
Pfam PF00178 (Ets)
PF02198 (SAM_PNT)

Target Cross References - Structure

PDBe 4IRG 4IRH 4IRI
CREDO 4IRG 4IRH 4IRI
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