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Target Report Card

Target Name and Classification

Target ID CHEMBL1287627
Preferred Name Cytochrome b-245 heavy chain
Synonyms CGD91-phox | CYBB | Cytochrome b(558) subunit beta | Cytochrome b-245 heavy chain | Cytochrome b558 subunit beta | Heme-binding membrane glycoprotein gp91phox | NADPH oxidase 2 | NOX2 | Neutrophil cytochrome b 91 kDa polypeptide | Superoxide-generating NADPH oxidase heavy chain subunit | gp91-1 | gp91-phox | p22 phagocyte B-cytochrome
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > transmembrane 1-electron transfer carriers

Target Components

Component Description Relationship Accession
Cytochrome b-245 heavy chain SINGLE PROTEIN P04839

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165168
Ensembl ENSG00000165168
GO Cellular Component GO:0005622 (intracellular)
GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005791 (rough endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0030670 (phagocytic vesicle membrane)
GO:0035579 (specific granule membrane)
GO:0043020 (NADPH oxidase complex)
GO:0043025 (neuronal cell body)
GO:0045335 (phagocytic vesicle)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070821 (tertiary granule membrane)
GO Molecular Function GO:0005244 (voltage-gated ion channel activity)
GO:0005515 (protein binding)
GO:0009055 (electron carrier activity)
GO:0016175 (superoxide-generating NADPH oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0050660 (flavin adenine dinucleotide binding)
GO Biological Process GO:0002479 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)
GO:0006801 (superoxide metabolic process)
GO:0006811 (ion transport)
GO:0006954 (inflammatory response)
GO:0007584 (response to nutrient)
GO:0022900 (electron transport chain)
GO:0034220 (ion transmembrane transport)
GO:0034599 (cellular response to oxidative stress)
GO:0034765 (regulation of ion transmembrane transport)
GO:0042493 (response to drug)
GO:0042535 (positive regulation of tumor necrosis factor biosynthetic process)
GO:0042554 (superoxide anion generation)
GO:0043312 (neutrophil degranulation)
GO:0045087 (innate immune response)
GO:0045454 (cell redox homeostasis)
GO:0045730 (respiratory burst)
GO:0045766 (positive regulation of angiogenesis)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0050665 (hydrogen peroxide biosynthetic process)
GO:0055114 (oxidation-reduction process)
GO:0071276 (cellular response to cadmium ion)
GO:0071361 (cellular response to ethanol)
GO:0071456 (cellular response to hypoxia)
GO:0097411 (hypoxia-inducible factor-1alpha signaling pathway)
GO:1904044 (response to aldosterone)
GO:1904845 (cellular response to L-glutamine)
GO:1990776 (response to angiotensin)
Wikipedia CYBB

Target Cross References - Protein

CGD Chronic granulomatous disease, X-linked; Atypical mycobacteriosis, familial, X-linked 2
Human Protein Atlas ENSG00000165168
IntAct P04839
Open Targets ENSG00000165168
PharmGKB PA27076
Pharos P04839 (Tchem)
Reactome R-HSA-1222556 (ROS, RNS production in phagocytes.)
R-HSA-1236973 (Cross-presentation of particulate exogenous antigens (phagosomes).)
R-HSA-3299685 (Detoxification of Reactive Oxygen Species.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-5668599 (RHO GTPases Activate NADPH Oxidases.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt A8K138 P04839 Q2PP16

Target Cross References - Domain

InterPro IPR000778 (Cyt_b245_heavy_chain.)
IPR013112 (FAD-bd_8.)
IPR013121 (Fe_red_NAD-bd_6.)
IPR013130 (Fe3_Rdtase_TM_dom.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR017938 (Riboflavin_synthase-like_b-brl.)
Pfam PF01794 (Ferric_reduct)
PF08022 (FAD_binding_8)
PF08030 (NAD_binding_6)

Target Cross References - Structure