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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL1287617
Target Type SINGLE PROTEIN
Preferred Name UDP-glucuronosyltransferase 1-1
Synonyms Bilirubin-specific UDPGT isozyme 1 | GNT1 | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | hUG-BR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
UDP-glucuronosyltransferase 1-1 SINGLE PROTEIN P22309

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000241635
Ensembl ENSG00000241635
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0005789 (endoplasmic reticulum membrane)
GO:0034663 (endoplasmic reticulum chaperone complex)
GO:0070069 (cytochrome complex)
GO:0005783 (endoplasmic reticulum)
GO Molecular Function GO:0001972 (retinoic acid binding)
GO:0015020 (glucuronosyltransferase activity)
GO:0019899 (enzyme binding)
GO:0042803 (protein homodimerization activity)
GO:0005496 (steroid binding)
GO:0004857 (enzyme inhibitor activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001889 (liver development)
GO:0007586 (digestion)
GO:0009813 (flavonoid biosynthetic process)
GO:0043086 (negative regulation of catalytic activity)
GO:0070980 (biphenyl catabolic process)
GO:0008202 (steroid metabolic process)
GO:0042167 (heme catabolic process)
GO:0042493 (response to drug)
GO:0044281 (small molecule metabolic process)
GO:0051552 (flavone metabolic process)
GO:1904224 (negative regulation of glucuronosyltransferase activity)
GO:0006805 (xenobiotic metabolic process)
GO:0017144 (drug metabolic process)
GO:0031100 (organ regeneration)
GO:0032870 (cellular response to hormone stimulus)
GO:0042594 (response to starvation)
GO:0045922 (negative regulation of fatty acid metabolic process)
GO:0052697 (xenobiotic glucuronidation)
GO:0071361 (cellular response to ethanol)
GO:0045939 (negative regulation of steroid metabolic process)
GO:0052695 (cellular glucuronidation)
GO:0007584 (response to nutrient)
GO:0006789 (bilirubin conjugation)
GO:0006953 (acute-phase response)
GO:0008210 (estrogen metabolic process)
GO:0046483 (heterocycle metabolic process)
GO:0006778 (porphyrin-containing compound metabolic process)
GO:0052696 (flavonoid glucuronidation)
GO:0071385 (cellular response to glucocorticoid stimulus)
GO:0032496 (response to lipopolysaccharide)
GO:0042573 (retinoic acid metabolic process)
GO:2001030 (negative regulation of cellular glucuronidation)
Wikipedia UDP_glucuronosyltransferase_1_family,_polypeptide_A1

Target Cross References - Protein

CGD Crigler-Najjar syndrome, type I; Crigler-Najjar syndrome, type II; Gilbert syndrome
Human Protein Atlas ENSG00000241635
IntAct P22309
PharmGKB PA420
UniProt P22309

Target Cross References - Domain

InterPro IPR002213 (UDP_glucos_trans.)
Pfam PF00201 (UDPGT)
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