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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1275223
Target Type SINGLE PROTEIN
Preferred Name Heat shock cognate 71 kDa protein
Synonyms HSC70 | HSP73 | HSPA10 | HSPA8 | Heat shock 70 kDa protein 8 | Heat shock cognate 71 kDa protein | LAP-1 | LPS-associated protein 1 | Lipopolysaccharide-associated protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Heat shock cognate 71 kDa protein SINGLE PROTEIN P11142

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105726 FORIGERIMOD ACETATE Heat shock cognate 71 kDa protein inhibitor 3 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109971
Ensembl ENSG00000109971
GO Cellular Component GO:0000151 (ubiquitin ligase complex)
GO:0000974 (Prp19 complex)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005681 (spliceosomal complex)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005765 (lysosomal membrane)
GO:0005770 (late endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005913 (cell-cell adherens junction)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0030529 (intracellular ribonucleoprotein complex)
GO:0031012 (extracellular matrix)
GO:0042470 (melanosome)
GO:0043202 (lysosomal lumen)
GO:0043209 (myelin sheath)
GO:0061202 (clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO:0098575 (lumenal side of lysosomal membrane)
GO:0098793 (presynapse)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001664 (G-protein coupled receptor binding)
GO:0001786 (phosphatidylserine binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016887 (ATPase activity)
GO:0019899 (enzyme binding)
GO:0023026 (MHC class II protein complex binding)
GO:0031072 (heat shock protein binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042623 (ATPase activity, coupled)
GO:0044822 (poly(A) RNA binding)
GO:0051082 (unfolded protein binding)
GO:0055131 (C3HC4-type RING finger domain binding)
GO:0098641 (cadherin binding involved in cell-cell adhesion)
GO Biological Process GO:0000398 (mRNA splicing, via spliceosome)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006397 (mRNA processing)
GO:0006457 (protein folding)
GO:0006622 (protein targeting to lysosome)
GO:0006986 (response to unfolded protein)
GO:0007269 (neurotransmitter secretion)
GO:0008380 (RNA splicing)
GO:0009267 (cellular response to starvation)
GO:0016032 (viral process)
GO:0031647 (regulation of protein stability)
GO:0042026 (protein refolding)
GO:0043254 (regulation of protein complex assembly)
GO:0043488 (regulation of mRNA stability)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0046034 (ATP metabolic process)
GO:0048026 (positive regulation of mRNA splicing, via spliceosome)
GO:0051085 (chaperone mediated protein folding requiring cofactor)
GO:0051726 (regulation of cell cycle)
GO:0061635 (regulation of protein complex stability)
GO:0061684 (chaperone-mediated autophagy)
GO:0061738 (late endosomal microautophagy)
GO:0061740 (protein targeting to lysosome involved in chaperone-mediated autophagy)
GO:0061741 (chaperone-mediated protein transport involved in chaperone-mediated autophagy)
GO:0072318 (clathrin coat disassembly)
GO:0098609 (cell-cell adhesion)
GO:1900034 (regulation of cellular response to heat)
GO:1902904 (negative regulation of fibril organization)
GO:1904589 (regulation of protein import)
GO:1904764 (chaperone-mediated autophagy translocation complex disassembly)
Wikipedia HSPA8

Target Cross References - Protein

Human Protein Atlas ENSG00000109971
IntAct P11142
Open Targets ENSG00000109971
PharmGKB PA29507
Reactome R-HSA-3371453 (Regulation of HSF1-mediated heat shock response.)
R-HSA-3371568 (Attenuation phase.)
R-HSA-3371571 (HSF1-dependent transactivation.)
R-HSA-432720 (Lysosome Vesicle Biogenesis.)
R-HSA-432722 (Golgi Associated Vesicle Biogenesis.)
R-HSA-447041 (CHL1 interactions.)
R-HSA-450408 (AUF1 (hnRNP D0) binds and destabilizes mRNA.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-72163 (mRNA Splicing - Major Pathway.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
R-HSA-8876725 (Protein methylation.)
R-HSA-888590 (GABA synthesis, release, reuptake and degradation.)
UniProt P11142 Q9H3R6

Target Cross References - Domain

InterPro IPR013126 (Hsp_70_fam.)
IPR018181 (Heat_shock_70_CS.)
IPR029047 (HSP70_peptide-bd.)
IPR029048 (HSP70_C.)
Pfam PF00012 (HSP70)

Target Cross References - Structure

PDBe 3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL More...
CREDO 3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL More...
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