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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1255167
Target Type SINGLE PROTEIN
Preferred Name Axin-2
Synonyms AXIN2 | Axil | Axin-2 | Axin-like protein | Axis inhibition protein 2 | Conductin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Axin-2 SINGLE PROTEIN Q9Y2T1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000168646
Ensembl ENSG00000168646
GO Cellular Component GO:0005634 (nucleus)
GO:0005813 (centrosome)
GO:0005881 (cytoplasmic microtubule)
GO:0005886 (plasma membrane)
GO:0005938 (cell cortex)
GO:0014069 (postsynaptic density)
GO:0016023 (cytoplasmic membrane-bounded vesicle)
GO:0034747 (Axin-APC-beta-catenin-GSK3B complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0005096 (GTPase activator activity)
GO:0008013 (beta-catenin binding)
GO:0019901 (protein kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0070016 (armadillo repeat domain binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0001957 (intramembranous ossification)
GO:0008285 (negative regulation of cell proliferation)
GO:0009950 (dorsal/ventral axis specification)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0010942 (positive regulation of cell death)
GO:0032423 (regulation of mismatch repair)
GO:0034613 (cellular protein localization)
GO:0035414 (negative regulation of catenin import into nucleus)
GO:0042476 (odontogenesis)
GO:0043570 (maintenance of DNA repeat elements)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0048255 (mRNA stabilization)
GO:0070602 (regulation of centromeric sister chromatid cohesion)
GO:0071407 (cellular response to organic cyclic compound)
GO:0090090 (negative regulation of canonical Wnt receptor signaling pathway)
GO:0090244 (Wnt receptor signaling pathway involved in somitogenesis)
Wikipedia AXIN2

Target Cross References - Protein

CGD Oligodontia-colorectal cancer syndrome
Human Protein Atlas ENSG00000168646
PharmGKB PA25196
UniProt Q3MJ88 Q9H3M6 Q9UH84 Q9Y2T1

Target Cross References - Domain

InterPro IPR000342 (Regulat_G_prot_signal.)
IPR001158 (DIX.)
IPR014936 (Axin_b-cat-bd.)
IPR016137 (Regulat_G_prot_signal_superfam.)
Pfam PF00615 (RGS)
PF00778 (DIX)
PF08833 (Axin_b-cat_bind)
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