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Target Report Card

Target Name and Classification

Target ID CHEMBL1255167
Preferred Name Axin-2
Synonyms AXIN2 | Axil | Axin-2 | Axin-like protein | Axis inhibition protein 2 | Conductin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168646
Ensembl ENSG00000168646
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005881 (cytoplasmic microtubule)
GO:0005886 (plasma membrane)
GO:0005938 (cell cortex)
GO:0014069 (postsynaptic density)
GO:0015630 (microtubule cytoskeleton)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0030877 (beta-catenin destruction complex)
GO Molecular Function GO:0005096 (GTPase activator activity)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0070016 (armadillo repeat domain binding)
GO:0070411 (I-SMAD binding)
GO Biological Process GO:0001756 (somitogenesis)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001957 (intramembranous ossification)
GO:0003139 (secondary heart field specification)
GO:0003413 (chondrocyte differentiation involved in endochondral bone morphogenesis)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007275 (multicellular organism development)
GO:0008283 (cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009950 (dorsal/ventral axis specification)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0010942 (positive regulation of cell death)
GO:0016055 (Wnt signaling pathway)
GO:0030111 (regulation of Wnt signaling pathway)
GO:0030282 (bone mineralization)
GO:0032423 (regulation of mismatch repair)
GO:0034613 (cellular protein localization)
GO:0035414 (negative regulation of catenin import into nucleus)
GO:0042476 (odontogenesis)
GO:0043547 (positive regulation of GTPase activity)
GO:0043570 (maintenance of DNA repeat elements)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0048255 (mRNA stabilization)
GO:0061181 (regulation of chondrocyte development)
GO:0070602 (regulation of centromeric sister chromatid cohesion)
GO:0071407 (cellular response to organic cyclic compound)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090244 (Wnt signaling pathway involved in somitogenesis)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1904837 (beta-catenin-TCF complex assembly)
Wikipedia AXIN2

Target Cross References - Protein

CGD Oligodontia-colorectal cancer syndrome
Human Protein Atlas ENSG00000168646
IntAct Q9Y2T1
Open Targets ENSG00000168646
PharmGKB PA25196
Reactome R-HSA-201681 (TCF dependent signaling in response to WNT.)
R-HSA-4411364 (Binding of TCF/LEF:CTNNB1 to target gene promoters.)
R-HSA-4641257 (Degradation of AXIN.)
R-HSA-5689880 (Ub-specific processing proteases.)
UniProt Q3MJ88 Q9H3M6 Q9UH84 Q9Y2T1

Target Cross References - Domain

InterPro IPR001158 (DIX.)
IPR014936 (Axin_b-cat-bd.)
IPR016137 (RGS.)
IPR024066 (RGS_subdom1.)
IPR029071 (Ubiquitin-rel_dom.)
IPR032101 (Axin_TNKS-bd.)
Pfam PF00615 (RGS)
PF00778 (DIX)
PF08833 (Axin_b-cat_bind)