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Target Report Card

Target Name and Classification

Target ID CHEMBL1255137
Preferred Name Protein Wnt-3a
Synonyms Protein Wnt-3a | WNT3A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Protein Wnt-3a SINGLE PROTEIN P56704

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000154342
Ensembl ENSG00000154342
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005796 (Golgi lumen)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0030666 (endocytic vesicle membrane)
GO:0031901 (early endosome membrane)
GO:0070062 (extracellular exosome)
GO:0098793 (presynapse)
GO:1990851 (Wnt-Frizzled-LRP5/6 complex)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0005102 (receptor binding)
GO:0005109 (frizzled binding)
GO:0005110 (frizzled-2 binding)
GO:0005515 (protein binding)
GO:0019904 (protein domain specific binding)
GO:0039706 (co-receptor binding)
GO:0048018 (receptor agonist activity)
GO Biological Process GO:0001649 (osteoblast differentiation)
GO:0001701 (in utero embryonic development)
GO:0001756 (somitogenesis)
GO:0001819 (positive regulation of cytokine production)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001947 (heart looping)
GO:0002092 (positive regulation of receptor internalization)
GO:0003136 (negative regulation of heart induction by canonical Wnt signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007368 (determination of left/right symmetry)
GO:0007409 (axonogenesis)
GO:0007411 (axon guidance)
GO:0007416 (synapse assembly)
GO:0007498 (mesoderm development)
GO:0008284 (positive regulation of cell proliferation)
GO:0009952 (anterior/posterior pattern specification)
GO:0010387 (COP9 signalosome assembly)
GO:0010977 (negative regulation of neuron projection development)
GO:0016055 (Wnt signaling pathway)
GO:0021527 (spinal cord association neuron differentiation)
GO:0021766 (hippocampus development)
GO:0021846 (cell proliferation in forebrain)
GO:0021874 (Wnt signaling pathway involved in forebrain neuroblast division)
GO:0021904 (dorsal/ventral neural tube patterning)
GO:0022008 (neurogenesis)
GO:0030097 (hemopoiesis)
GO:0030168 (platelet activation)
GO:0030182 (neuron differentiation)
GO:0030198 (extracellular matrix organization)
GO:0030879 (mammary gland development)
GO:0030890 (positive regulation of B cell proliferation)
GO:0030901 (midbrain development)
GO:0032092 (positive regulation of protein binding)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033278 (cell proliferation in midbrain)
GO:0034613 (cellular protein localization)
GO:0035413 (positive regulation of catenin import into nucleus)
GO:0035914 (skeletal muscle cell differentiation)
GO:0036342 (post-anal tail morphogenesis)
GO:0036465 (synaptic vesicle recycling)
GO:0042472 (inner ear morphogenesis)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0045595 (regulation of cell differentiation)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045860 (positive regulation of protein kinase activity)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048103 (somatic stem cell division)
GO:0048337 (positive regulation of mesodermal cell fate specification)
GO:0048343 (paraxial mesodermal cell fate commitment)
GO:0048643 (positive regulation of skeletal muscle tissue development)
GO:0048697 (positive regulation of collateral sprouting in absence of injury)
GO:0048843 (negative regulation of axon extension involved in axon guidance)
GO:0050768 (negative regulation of neurogenesis)
GO:0050770 (regulation of axonogenesis)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0060021 (palate development)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060923 (cardiac muscle cell fate commitment)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0061184 (positive regulation of dermatome development)
GO:0061317 (canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)
GO:0070507 (regulation of microtubule cytoskeleton organization)
GO:0070527 (platelet aggregation)
GO:0071300 (cellular response to retinoic acid)
GO:0090245 (axis elongation involved in somitogenesis)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1903078 (positive regulation of protein localization to plasma membrane)
GO:1904339 (negative regulation of dopaminergic neuron differentiation)
GO:1904886 (beta-catenin destruction complex disassembly)
GO:1904953 (Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)
GO:2000049 (positive regulation of cell-cell adhesion mediated by cadherin)
GO:2000081 (positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)
GO:2000179 (positive regulation of neural precursor cell proliferation)
GO:2000347 (positive regulation of hepatocyte proliferation)
GO:2000679 (positive regulation of transcription regulatory region DNA binding)
GO:2000727 (positive regulation of cardiac muscle cell differentiation)
Wikipedia WNT3A

Target Cross References - Protein

Human Protein Atlas ENSG00000154342
IntAct P56704
Open Targets ENSG00000154342
PharmGKB PA38074
Reactome R-HSA-201681 (TCF dependent signaling in response to WNT.)
R-HSA-3238698 (WNT ligand biogenesis and trafficking.)
R-HSA-373080 (Class B/2 (Secretin family receptors).)
R-HSA-3772470 (Negative regulation of TCF-dependent signaling by WNT ligand antagonists.)
R-HSA-4641262 (Disassembly of the destruction complex and recruitment of AXIN to the membrane.)
R-HSA-4641263 (Regulation of FZD by ubiquitination.)
R-HSA-5340588 (RNF mutants show enhanced WNT signaling and proliferation.)
UniProt P56704 Q3SY79 Q3SY80 Q969P2

Target Cross References - Domain

InterPro IPR005817 (Wnt.)
IPR009141 (Wnt3.)
IPR018161 (Wnt_CS.)
Pfam PF00110 (wnt)