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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1255137
Target Type SINGLE PROTEIN
Preferred Name Protein Wnt-3a
Synonyms Protein Wnt-3a | WNT3A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Protein Wnt-3a SINGLE PROTEIN P56704

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000154342
Ensembl ENSG00000154342
GO Cellular Component GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0045121 (membrane raft)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0004871 (signal transducer activity)
GO:0005110 (frizzled-2 binding)
GO:0005201 (extracellular matrix structural constituent)
GO:0048018 (receptor agonist activity)
GO Biological Process GO:0002092 (positive regulation of receptor internalization)
GO:0003136 (negative regulation of heart induction by canonical Wnt receptor signaling pathway)
GO:0007223 (Wnt receptor signaling pathway, calcium modulating pathway)
GO:0007267 (cell-cell signaling)
GO:0009798 (axis specification)
GO:0009880 (embryonic pattern specification)
GO:0010387 (signalosome assembly)
GO:0010977 (negative regulation of neuron projection development)
GO:0021766 (hippocampus development)
GO:0021846 (cell proliferation in forebrain)
GO:0021874 (Wnt receptor signaling pathway involved in forebrain neuroblast division)
GO:0021904 (dorsal/ventral neural tube patterning)
GO:0030198 (extracellular matrix organization)
GO:0030879 (mammary gland development)
GO:0030903 (notochord development)
GO:0030917 (midbrain-hindbrain boundary development)
GO:0032092 (positive regulation of protein binding)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0035121 (tail morphogenesis)
GO:0035413 (positive regulation of catenin import into nucleus)
GO:0042472 (inner ear morphogenesis)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048343 (paraxial mesodermal cell fate commitment)
GO:0060021 (palate development)
GO:0060026 (convergent extension)
GO:0061054 (dermatome development)
GO:0071300 (cellular response to retinoic acid)
GO:0071425 (hemopoietic stem cell proliferation)
Wikipedia WNT3A

Target Cross References - Protein

Human Protein Atlas ENSG00000154342
PharmGKB PA38074
Reactome REACT_14797 (Signaling by GPCR.)
UniProt P56704 Q3SY80 Q969P2

Target Cross References - Domain

InterPro IPR005816 (Wnt_grthfactor.)
IPR005817 (Wnt_SF.)
IPR009141 (Wnt3.)
IPR018161 (Wnt_grthfactor_CS.)
Pfam PF00110 (wnt)
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