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Target Report Card

Target Name and Classification

Target ID CHEMBL1255132
Preferred Name Protein Wnt-2
Synonyms INT1L1 | IRP | IRP | Int-1-like protein 1 | Int-1-related protein | Protein Wnt-2 | WNT2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Protein Wnt-2 SINGLE PROTEIN P09544

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105989
Ensembl ENSG00000105989
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0031012 (extracellular matrix)
GO:1990909 (Wnt signalosome)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005109 (frizzled binding)
GO:0005125 (cytokine activity)
GO:0005515 (protein binding)
GO:0048018 (receptor agonist activity)
GO Biological Process GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0002088 (lens development in camera-type eye)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organism development)
GO:0008284 (positive regulation of cell proliferation)
GO:0016055 (Wnt signaling pathway)
GO:0022008 (neurogenesis)
GO:0030182 (neuron differentiation)
GO:0030324 (lung development)
GO:0033278 (cell proliferation in midbrain)
GO:0045165 (cell fate commitment)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0050769 (positive regulation of neurogenesis)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0055009 (atrial cardiac muscle tissue morphogenesis)
GO:0060045 (positive regulation of cardiac muscle cell proliferation)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060317 (cardiac epithelial to mesenchymal transition)
GO:0060492 (lung induction)
GO:0060501 (positive regulation of epithelial cell proliferation involved in lung morphogenesis)
GO:0060716 (labyrinthine layer blood vessel development)
GO:0061072 (iris morphogenesis)
GO:0061180 (mammary gland epithelium development)
GO:0071300 (cellular response to retinoic acid)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1904948 (midbrain dopaminergic neuron differentiation)
GO:1904954 (canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)
Wikipedia WNT2

Target Cross References - Protein

Human Protein Atlas ENSG00000105989
IntAct P09544
Open Targets ENSG00000105989
PharmGKB PA37381
Reactome R-HSA-3238698 (WNT ligand biogenesis and trafficking.)
R-HSA-373080 (Class B/2 (Secretin family receptors).)
UniProt A4D0V1 P09544 Q75N05 Q9UDP9

Target Cross References - Domain

InterPro IPR005817 (Wnt.)
IPR009140 (Wnt2.)
IPR018161 (Wnt_CS.)
Pfam PF00110 (wnt)