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Target Report Card

Target Name and Classification

Target ID CHEMBL1255127
Target Type SINGLE PROTEIN
Preferred Name Axin-1
Synonyms AXIN | AXIN1 | Axin-1 | Axis inhibition protein 1 | hAxin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Axin-1 SINGLE PROTEIN O15169

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038464 Axin1/beta-catenin PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000103126
Ensembl ENSG00000103126
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005881 (cytoplasmic microtubule)
GO:0005886 (plasma membrane)
GO:0005938 (cell cortex)
GO:0014069 (postsynaptic density)
GO:0016023 (cytoplasmic membrane-bounded vesicle)
GO:0016328 (lateral plasma membrane)
GO:0030877 (beta-catenin destruction complex)
GO:0031410 (cytoplasmic vesicle)
GO:0034742 (APC-Axin-1-beta-catenin complex)
GO:0034747 (Axin-APC-beta-catenin-GSK3B complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0071944 (cell periphery)
GO Molecular Function GO:0002039 (p53 binding)
GO:0004871 (signal transducer activity)
GO:0005096 (GTPase activator activity)
GO:0008013 (beta-catenin binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0032947 (protein complex scaffold)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046332 (SMAD binding)
GO:0070016 (armadillo repeat domain binding)
GO:0070411 (I-SMAD binding)
GO Biological Process GO:0000209 (protein polyubiquitination)
GO:0001701 (in utero embryonic development)
GO:0001743 (optic placode formation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006913 (nucleocytoplasmic transport)
GO:0006915 (apoptosis)
GO:0006915 (apoptotic process)
GO:0007257 (activation of JUN kinase activity)
GO:0007368 (determination of left/right symmetry)
GO:0007605 (sensory perception of sound)
GO:0008219 (cell death)
GO:0009950 (dorsal/ventral axis specification)
GO:0010800 (positive regulation of peptidyl-threonine phosphorylation)
GO:0021797 (forebrain anterior/posterior pattern formation)
GO:0021797 (forebrain anterior/posterior pattern specification)
GO:0021881 (Wnt receptor signaling pathway involved in forebrain neuron fate commitment)
GO:0021881 (Wnt-activated signaling pathway involved in forebrain neuron fate commitment)
GO:0030154 (cell differentiation)
GO:0030163 (protein catabolic process)
GO:0030178 (negative regulation of Wnt signaling pathway)
GO:0030511 (positive regulation of transforming growth factor beta receptor signaling pathway)
GO:0030910 (olfactory placode formation)
GO:0031122 (cytoplasmic microtubule organization)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0032147 (activation of protein kinase activity)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034244 (negative regulation of transcription elongation from RNA polymerase II promoter)
GO:0035121 (tail morphogenesis)
GO:0035412 (regulation of catenin import into nucleus)
GO:0036342 (post-anal tail morphogenesis)
GO:0043547 (positive regulation of GTPase activity)
GO:0043623 (cellular protein complex assembly)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045732 (positive regulation of protein catabolic process)
GO:0045893 (positive regulation of transcription, DNA-dependent)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046330 (positive regulation of JNK cascade)
GO:0048048 (embryonic eye morphogenesis)
GO:0048320 (axial mesoderm formation)
GO:0051248 (negative regulation of protein metabolic process)
GO:0051260 (protein homooligomerization)
GO:0051443 (positive regulation of ubiquitin-protein ligase activity)
GO:0051443 (positive regulation of ubiquitin-protein transferase activity)
GO:0055001 (muscle cell development)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060272 (embryonic skeletal joint morphogenesis)
GO:0060823 (canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation)
GO:0060823 (canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071514 (genetic imprinting)
GO:0090090 (negative regulation of canonical Wnt receptor signaling pathway)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090244 (Wnt receptor signaling pathway involved in somitogenesis)
GO:0090244 (Wnt signaling pathway involved in somitogenesis)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:2000060 (positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
Wikipedia AXIN1

Target Cross References - Protein

CGD Caudal duplication anomaly
Human Protein Atlas ENSG00000103126
IntAct O15169
PharmGKB PA25195
UniProt O15169 Q4TT26 Q4TT27 Q86YA7 Q8WVW6 Q96S28

Target Cross References - Domain

InterPro IPR000342 (Regulat_G_prot_signal.)
IPR001158 (DIX.)
IPR014936 (Axin_b-cat-bd.)
IPR016137 (RGS.)
IPR016137 (Regulat_G_prot_signal_superfam.)
IPR024066 (RGS_subdom1.)
IPR029071 (Ubiquitin-rel_dom.)
IPR029797 (AXIN1.)
IPR032101 (Axin_TNKS_BD.)
Pfam PF00615 (RGS)
PF00778 (DIX)
PF08833 (Axin_b-cat_bind)
PF16646 (AXIN1_TNKS_BD)

Target Cross References - Structure

PDBe 1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1
CREDO 1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1
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