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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1250417
Target Type SINGLE PROTEIN
Preferred Name Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Synonyms HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > cyclic nucleotide-regulated channel

Target Components

Component Description Relationship Accession
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 SINGLE PROTEIN Q9Y3Q4

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201729 DRONEDARONE HYDROCHLORIDE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker 4 PubMed PubMed PubMed PubMed PubMed
CHEMBL2145077 IVABRADINE HYDROCHLORIDE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138622
Ensembl ENSG00000138622
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031226 (intrinsic component of plasma membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO:0098855 (HCN channel complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005216 (ion channel activity)
GO:0005222 (intracellular cAMP activated cation channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005249 (voltage-gated potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0005272 (sodium channel activity)
GO:0030552 (cAMP binding)
GO:0042802 (identical protein binding)
GO:0086041 (voltage-gated potassium channel activity involved in SA node cell action potential depolarization)
GO Biological Process GO:0002027 (regulation of heart rate)
GO:0003254 (regulation of membrane depolarization)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006813 (potassium ion transport)
GO:0006814 (sodium ion transport)
GO:0006936 (muscle contraction)
GO:0008015 (blood circulation)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042391 (regulation of membrane potential)
GO:0055085 (transmembrane transport)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0071320 (cellular response to cAMP)
GO:0071321 (cellular response to cGMP)
GO:0071805 (potassium ion transmembrane transport)
GO:0086012 (membrane depolarization during cardiac muscle cell action potential)
GO:0086015 (SA node cell action potential)
GO:0086046 (membrane depolarization during SA node cell action potential)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:0098719 (sodium ion import across plasma membrane)
GO:0098909 (regulation of cardiac muscle cell action potential involved in regulation of contraction)
GO:1990573 (potassium ion import across plasma membrane)
Wikipedia HCN4

Target Cross References - Protein

CGD Brugada syndrome 8; Sick sinus syndrome 2
Human Protein Atlas ENSG00000138622
IntAct Q9Y3Q4
Guide to Pharmacology 403
Open Targets ENSG00000138622
PharmGKB PA394
Pharos Q9Y3Q4 (Tclin)
Reactome R-HSA-1296061 (HCN channels.)
UniProt Q9UMQ7 Q9Y3Q4

Target Cross References - Domain

InterPro IPR000595 (cNMP-bd_dom.)
IPR003938 (K_chnl_volt-dep_EAG/ELK/ERG.)
IPR005821 (Ion_trans_dom.)
IPR013621 (Ion_trans_N.)
IPR014710 (RmlC-like_jellyroll.)
IPR018488 (cNMP-bd_CS.)
IPR018490 (cNMP-bd-like.)
IPR027359 (Volt_channel_dom_sf.)
IPR030173 (HCN4.)
Pfam PF00027 (cNMP_binding)
PF00520 (Ion_trans)
PF08412 (Ion_trans_N)

Target Cross References - Structure

PDBe 3OTF 3U11 4HBN 4KL1 4NVP
CREDO 3OTF 3U11 4HBN 4KL1 4NVP
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