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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1250415
Target Type SINGLE PROTEIN
Preferred Name Beta-hexosaminidase subunit alpha
Synonyms Beta-N-acetylhexosaminidase subunit alpha | Beta-hexosaminidase subunit alpha | HEXA | Hexosaminidase subunit A | N-acetyl-beta-glucosaminidase subunit alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Beta-hexosaminidase subunit alpha SINGLE PROTEIN P06865

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038485 Beta-N-acetyl-D-hexosaminidase-A/B PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000213614
Ensembl ENSG00000213614
GO Cellular Component GO:0005764 (lysosome)
GO:0016020 (membrane)
GO:0042582 (azurophil granule)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
GO:0004563 (beta-N-acetylhexosaminidase activity)
GO:0008375 (acetylglucosaminyltransferase activity)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006024 (glycosaminoglycan biosynthetic process)
GO:0006687 (glycosphingolipid metabolic process)
GO:0008152 (metabolic process)
GO:0030207 (chondroitin sulfate catabolic process)
GO:0030214 (hyaluronan catabolic process)
GO:0042340 (keratan sulfate catabolic process)
Wikipedia HEXA

Target Cross References - Protein

CGD Tay-Sachs disease; GM2-gangliosidosis; Hexosaminidase A deficiency
Human Protein Atlas ENSG00000213614
IntAct P06865
Open Targets ENSG00000213614
PharmGKB PA29256
Reactome R-HSA-1660662 (Glycosphingolipid metabolism.)
R-HSA-2022857 (Keratan sulfate degradation.)
R-HSA-2024101 (CS/DS degradation.)
R-HSA-2160916 (Hyaluronan uptake and degradation.)
UniProt B4DKE7 E7ENH7 P06865 Q53HS8 Q6AI32

Target Cross References - Domain

InterPro IPR013781 (Glyco_hydro_catalytic_dom.)
IPR015883 (Glyco_hydro_20_cat.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR025705 (Beta_hexosaminidase_sua/sub.)
IPR029018 (Chitobiase/Hex_dom_2-like.)
IPR029019 (HEX_eukaryotic_N.)
Pfam PF00728 (Glyco_hydro_20)
PF14845 (Glycohydro_20b2)

Target Cross References - Structure

PDBe 2GJX 2GK1
CREDO 2GJX 2GK1
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