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Target Report Card

Target Name and Classification

Target ID CHEMBL1250381
Target Type SINGLE PROTEIN
Preferred Name Dual specificity protein phosphatase 6
Synonyms DUSP6 | Dual specificity protein phosphatase 6 | Dual specificity protein phosphatase PYST1 | MAP kinase phosphatase 3 | MKP-3 | MKP3 | Mitogen-activated protein kinase phosphatase 3 | PYST1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Dual specificity protein phosphatase 6 SINGLE PROTEIN Q16828

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000139318
Ensembl ENSG00000139318
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0008138 (protein tyrosine/serine/threonine phosphatase activity)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0017017 (MAP kinase tyrosine/serine/threonine phosphatase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0000188 (inactivation of MAPK activity)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0006470 (protein dephosphorylation)
GO:0009953 (dorsal/ventral pattern formation)
GO:0010033 (response to organic substance)
GO:0010942 (positive regulation of cell death)
GO:0014070 (response to organic cyclic compound)
GO:0016311 (dephosphorylation)
GO:0030154 (cell differentiation)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0040036 (regulation of fibroblast growth factor receptor signaling pathway)
GO:0042493 (response to drug)
GO:0042663 (regulation of endodermal cell fate specification)
GO:0043065 (positive regulation of apoptotic process)
GO:0051409 (response to nitrosative stress)
GO:0060420 (regulation of heart growth)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0070848 (response to growth factor)
Wikipedia DUSP6

Target Cross References - Protein

Human Protein Atlas ENSG00000139318
IntAct Q16828
Open Targets ENSG00000139318
PharmGKB PA27529
Reactome R-HSA-112409 (RAF-independent MAPK1/3 activation.)
R-HSA-202670 (ERKs are inactivated.)
R-HSA-5675221 (Negative regulation of MAPK pathway.)
UniProt O75109 Q16828 Q53Y75 Q9BSH6

Target Cross References - Domain

InterPro IPR000340 (Dual-sp_phosphatase_cat-dom.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR001763 (Rhodanese-like_dom.)
IPR008343 (MKP.)
IPR020422 (TYR_PHOSPHATASE_DUAL_dom.)
IPR024950 (DUSP.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
IPR036873 (Rhodanese-like_dom_sf.)
Pfam PF00581 (Rhodanese)
PF00782 (DSPc)

Target Cross References - Structure

PDBe 1MKP
CREDO 1MKP
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