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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1250363
Target Type SINGLE PROTEIN
Preferred Name Protein max
Synonyms BHLHD4 | Class D basic helix-loop-helix protein 4 | MAX | Myc-associated factor X | Protein max | bHLHd4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Protein max SINGLE PROTEIN P61244

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301395 c-Myc/Max PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125952
Ensembl ENSG00000125952
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0016605 (PML body)
GO:0030425 (dendrite)
GO:0042995 (cell projection)
GO:0071339 (MLL1 complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000983 (transcription factor activity, RNA polymerase II core promoter sequence-specific)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003712 (transcription cofactor activity)
GO:0003713 (transcription coactivator activity)
GO:0005515 (protein binding)
GO:0032403 (protein complex binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0046982 (protein heterodimerization activity)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006461 (protein complex assembly)
GO:0009267 (cellular response to starvation)
GO:0010243 (response to organonitrogen compound)
GO:0010629 (negative regulation of gene expression)
GO:0032868 (response to insulin)
GO:0048678 (response to axon injury)
GO:0051402 (neuron apoptotic process)
GO:0060041 (retina development in camera-type eye)
GO:0071375 (cellular response to peptide hormone stimulus)
Wikipedia MAX_(gene)

Target Cross References - Protein

CGD Pheochromocytoma
Human Protein Atlas ENSG00000125952
IntAct P61244
Open Targets ENSG00000125952
PharmGKB PA30656
Reactome R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
TIMBAL Max
UniProt A6NH73 A8K265 A8K4G4 A8K824 P25912 P52163 P61244 Q14803 Q96CY8

Target Cross References - Domain

InterPro IPR011598 (bHLH_dom.)
Pfam PF00010 (HLH)

Target Cross References - Structure

PDBe 1AN2 1HLO 1NKP 1NLW 5EYO
CREDO 1AN2 1HLO 1NKP 1NLW 5EYO
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