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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1250360
Target Type SINGLE PROTEIN
Preferred Name Tumor necrosis factor receptor superfamily member 3
Synonyms D12S370 | LTBR | Lymphotoxin-beta receptor | TNF-RIII | TNFCR | TNFR-III | TNFR3 | TNFRSF3 | Tumor necrosis factor C receptor | Tumor necrosis factor receptor 2-related protein | Tumor necrosis factor receptor superfamily member 3 | Tumor necrosis factor receptor type III
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Tumor necrosis factor receptor superfamily member 3 SINGLE PROTEIN P36941

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111321
Ensembl ENSG00000111321
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005031 (tumor necrosis factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0016032 (viral process)
GO:0032496 (response to lipopolysaccharide)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0043011 (myeloid dendritic cell differentiation)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0046330 (positive regulation of JNK cascade)
GO:0071260 (cellular response to mechanical stimulus)
GO:2001238 (positive regulation of extrinsic apoptotic signaling pathway)
Wikipedia Lymphotoxin_beta_receptor

Target Cross References - Protein

Human Protein Atlas ENSG00000111321
IntAct P36941
Open Targets ENSG00000111321
PharmGKB PA30481
Reactome R-HSA-5668541 (TNFR2 non-canonical NF-kB pathway.)
R-HSA-5676594 (TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.)
UniProt B7Z1D2 D3DUR2 F5GXE7 P36941

Target Cross References - Domain

InterPro IPR001368 (TNFR/NGFR_Cys_rich_reg.)
IPR017349 (TNFR_3_LTBR.)
IPR033997 (TNFRSF3_N.)
Pfam PF00020 (TNFR_c6)

Target Cross References - Structure

PDBe 1RF3 4MXW
CREDO 1RF3 4MXW
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