ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1250358
Target Type SINGLE PROTEIN
Preferred Name Tumor necrosis factor receptor superfamily member 5
Synonyms B-cell surface antigen CD40 | Bp50 | CD40 | CD40L receptor | CD_antigen=CD40 | CDw40 | TNFRSF5 | Tumor necrosis factor receptor superfamily member 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Tumor necrosis factor receptor superfamily member 5 SINGLE PROTEIN P25942

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743005 DACETUZUMAB Tumor necrosis factor receptor superfamily member 5 inhibitor 2 PubMed
CHEMBL2108144 TENELIXIMAB Tumor necrosis factor receptor superfamily member 5 partial agonist 2 PubMed
CHEMBL2109475 PG-102 Tumor necrosis factor receptor superfamily member 5 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101017
Ensembl ENSG00000101017
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0035631 (CD40 receptor complex)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003823 (antigen binding)
GO:0004871 (signal transducer activity)
GO:0004872 (receptor activity)
GO:0005031 (tumor necrosis factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0019899 (enzyme binding)
GO:0031625 (ubiquitin protein ligase binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0002376 (immune system process)
GO:0002768 (immune response-regulating cell surface receptor signaling pathway)
GO:0006461 (protein complex assembly)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007275 (multicellular organism development)
GO:0030168 (platelet activation)
GO:0030890 (positive regulation of B cell proliferation)
GO:0032496 (response to lipopolysaccharide)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0042100 (B cell proliferation)
GO:0042113 (B cell activation)
GO:0042127 (regulation of cell proliferation)
GO:0042511 (positive regulation of tyrosine phosphorylation of Stat1 protein)
GO:0042832 (defense response to protozoan)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043491 (protein kinase B signaling)
GO:0043547 (positive regulation of GTPase activity)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048304 (positive regulation of isotype switching to IgG isotypes)
GO:0050776 (regulation of immune response)
GO:0051023 (regulation of immunoglobulin secretion)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051607 (defense response to virus)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071260 (cellular response to mechanical stimulus)
GO:0090037 (positive regulation of protein kinase C signaling)
GO:0097190 (apoptotic signaling pathway)
GO:2000353 (positive regulation of endothelial cell apoptotic process)
Wikipedia CD40_(protein)

Target Cross References - Protein

CGD Immunodeficiency with Hyper-IgM, type 3
Human Protein Atlas ENSG00000101017
IntAct P25942
Open Targets ENSG00000101017
PharmGKB PA36612
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-5668541 (TNFR2 non-canonical NF-kB pathway.)
R-HSA-5676594 (TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.)
TIMBAL CD154
UniProt E1P5S9 P25942 Q53GN5 Q5JY15 Q5U007 Q7M4Q8 Q86YK5 Q9BYU0

Target Cross References - Domain

InterPro IPR001368 (TNFR/NGFR_Cys_rich_reg.)
IPR020435 (TNFR_5.)
IPR034021 (TNFRSF5_N.)
Pfam PF00020 (TNFR_c6)

Target Cross References - Structure

PDBe 1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL
CREDO 1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL
spacer
spacer