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Target Report Card

Target Name and Classification

Target ID CHEMBL1250356
Target Type SINGLE PROTEIN
Preferred Name Tumor necrosis factor receptor superfamily member 1B
Synonyms CD_antigen=CD120b | INN=Etanercept | TBP-2 | TBPII | TNF-R2 | TNF-RII | TNFBR | TNFR-II | TNFR2 | TNFRSF1B | Tumor necrosis factor receptor 2 | Tumor necrosis factor receptor superfamily member 1B | Tumor necrosis factor receptor superfamily member 1b, membrane form | Tumor necrosis factor receptor type II | Tumor necrosis factor-binding protein 2 | p75 | p80 TNF-alpha receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Tumor necrosis factor receptor superfamily member 1B SINGLE PROTEIN P20333

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000028137
Ensembl ENSG00000028137
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0035579 (specific granule membrane)
GO:0043025 (neuronal cell body)
GO:0043196 (varicosity)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0005031 (tumor necrosis factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0031625 (ubiquitin protein ligase binding)
GO Biological Process GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007568 (aging)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0032496 (response to lipopolysaccharide)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043312 (neutrophil degranulation)
GO:0050728 (negative regulation of inflammatory response)
GO:0050779 (RNA destabilization)
GO:0051044 (positive regulation of membrane protein ectodomain proteolysis)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071363 (cellular response to growth factor stimulus)
GO:0097190 (apoptotic signaling pathway)
GO:0097191 (extrinsic apoptotic signaling pathway)
Wikipedia TNFRSF1B

Target Cross References - Protein

canSAR P20333
Human Protein Atlas ENSG00000028137
IntAct P20333
Open Targets ENSG00000028137
PharmGKB PA36610
Reactome R-HSA-5668541 (TNFR2 non-canonical NF-kB pathway.)
R-HSA-5669034 (TNFs bind their physiological receptors.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B1AJZ3 P20333 Q16042 Q6YI29 Q9UIH1

Target Cross References - Domain

InterPro IPR001368 (TNFR/NGFR_Cys_rich_reg.)
IPR020411 (TNFR_1B.)
IPR033996 (TNFRSF1B_N.)
Pfam PF00020 (TNFR_c6)

Target Cross References - Structure

PDBe 1CA9 3ALQ
CREDO 1CA9 3ALQ
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