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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1250350
Target Type SINGLE PROTEIN
Preferred Name Prolyl 4-hydroxylase subunit alpha-1
Synonyms 4-PH alpha-1 | P4HA | P4HA1 | Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 | Prolyl 4-hydroxylase subunit alpha-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Prolyl 4-hydroxylase subunit alpha-1 SINGLE PROTEIN P13674

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000122884
Ensembl ENSG00000122884
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005788 (endoplasmic reticulum lumen)
GO Molecular Function GO:0004656 (procollagen-proline 4-dioxygenase activity)
GO:0005506 (iron ion binding)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0031418 (L-ascorbic acid binding)
Wikipedia P4HA1

Target Cross References - Protein

Human Protein Atlas ENSG00000122884
PharmGKB PA32874
UniProt P13674 Q15082 Q15083 Q5VSQ5

Target Cross References - Domain

InterPro IPR005123 (Oxoglutarate/Fe-dep_oxygenase.)
IPR006620 (Pro_4_hyd_alph.)
IPR011990 (TPR-like_helical.)
IPR013026 (TPR-contain.)
IPR013547 (Pro_4_hyd_alph_N.)
IPR019734 (TPR_repeat.)
Pfam PF03171 (2OG-FeII_Oxy)
PF08336 (P4Ha_N)

Target Cross References - Structure

PDBe 1TJC 2V5F
CREDO 1TJC 2V5F
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