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Target Report Card

Target Name and Classification

Target ID CHEMBL1250348
Preferred Name Myc proto-oncogene protein
Synonyms BHLHE39 | Class E basic helix-loop-helix protein 39 | MYC | Myc proto-oncogene protein | Proto-oncogene c-Myc | Transcription factor p64 | bHLHe39
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Myc proto-oncogene protein SINGLE PROTEIN P01106

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136997
Ensembl ENSG00000136997
GO Cellular Component GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005829 (cytosol)
GO:0032991 (macromolecular complex)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0033613 (activating transcription factor binding)
GO:0044877 (macromolecular complex binding)
GO:0046983 (protein dimerization activity)
GO:0070491 (repressing transcription factor binding)
GO:0070888 (E-box binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000165 (MAPK cascade)
GO:0001658 (branching involved in ureteric bud morphogenesis)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0006112 (energy reserve metabolic process)
GO:0006338 (chromatin remodeling)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006879 (cellular iron ion homeostasis)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007050 (cell cycle arrest)
GO:0007219 (Notch signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0010332 (response to gamma radiation)
GO:0010468 (regulation of gene expression)
GO:0010628 (positive regulation of gene expression)
GO:0015671 (oxygen transport)
GO:0016579 (protein deubiquitination)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0032204 (regulation of telomere maintenance)
GO:0032873 (negative regulation of stress-activated MAPK cascade)
GO:0032986 (protein-DNA complex disassembly)
GO:0034644 (cellular response to UV)
GO:0035690 (cellular response to drug)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0044346 (fibroblast apoptotic process)
GO:0045656 (negative regulation of monocyte differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048147 (negative regulation of fibroblast proliferation)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0051276 (chromosome organization)
GO:0051782 (negative regulation of cell division)
GO:0051973 (positive regulation of telomerase activity)
GO:0060070 (canonical Wnt signaling pathway)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0070848 (response to growth factor)
GO:0071456 (cellular response to hypoxia)
GO:0090096 (positive regulation of metanephric cap mesenchymal cell proliferation)
GO:1904837 (beta-catenin-TCF complex assembly)
GO:2000573 (positive regulation of DNA biosynthetic process)
GO:2001022 (positive regulation of response to DNA damage stimulus)
Wikipedia Myc

Target Cross References - Protein

canSAR P01106
Human Protein Atlas ENSG00000136997
IntAct P01106
Open Targets ENSG00000136997
PharmGKB PA31353
Reactome R-HSA-1362277 (Transcription of E2F targets under negative control by DREAM complex.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2173796 (SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-4411364 (Binding of TCF/LEF:CTNNB1 to target gene promoters.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
R-HSA-8866911 (TFAP2 (AP-2) family regulates transcription of cell cycle factors.)
R-HSA-8951430 (RUNX3 regulates WNT signaling.)
UniProt A8WFE7 P01106 P01107 Q14026

Target Cross References - Domain

InterPro IPR002418 (Tscrpt_reg_Myc.)
IPR003327 (Myc-LZ.)
IPR011598 (bHLH_dom.)
IPR012682 (Tscrpt_reg_Myc_N.)
IPR036638 (HLH_DNA-bd_sf.)
Pfam PF00010 (HLH)
PF01056 (Myc_N)
PF02344 (Myc-LZ)

Target Cross References - Structure

PDBe 1EE4 1NKP 2OR9 4Y7R 5I4Z 5I50
CREDO 1EE4 1NKP 2OR9 4Y7R 5I4Z 5I50