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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1250348
Target Type SINGLE PROTEIN
Preferred Name Myc proto-oncogene protein
Synonyms BHLHE39 | Class E basic helix-loop-helix protein 39 | MYC | Myc proto-oncogene protein | Proto-oncogene c-Myc | Transcription factor p64 | bHLHe39
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Myc proto-oncogene protein SINGLE PROTEIN P01106

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3301395 c-Myc/Max PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136997
Ensembl ENSG00000136997
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0005515 (protein binding)
GO:0016563 (transcription activator activity)
GO:0070888 (E-box binding)
GO Biological Process GO:0001658 (branching involved in ureteric bud morphogenesis)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006879 (cellular iron ion homeostasis)
GO:0007050 (cell cycle arrest)
GO:0008283 (cell proliferation)
GO:0032204 (regulation of telomere maintenance)
GO:0042493 (response to drug)
GO:0045893 (positive regulation of transcription, DNA-dependent)
GO:0090096 (positive regulation of metanephric cap mesenchymal cell proliferation)
Wikipedia Myc

Target Cross References - Protein

canSAR P01106
Human Protein Atlas ENSG00000136997
IntAct P01106
PharmGKB PA31353
TIMBAL c-Myc
UniProt A8WFE7 P01106 P01107 Q14026

Target Cross References - Domain

InterPro IPR001092 (HLH_DNA-bd_dom.)
IPR002418 (Tscrpt_reg_Myc.)
IPR003327 (Myc-LZ.)
IPR011598 (HLH_DNA-bd.)
IPR012682 (Tscrpt_reg_Myc_N.)
Pfam PF00010 (HLH)
PF01056 (Myc_N)
PF02344 (Myc-LZ)

Target Cross References - Structure

PDBe 1EE4 1NKP
CREDO 1EE4 1NKP
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