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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1229012
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase complex subunit SAP130
Synonyms 130 kDa Sin3-associated polypeptide | Histone deacetylase complex subunit SAP130 | SAP130 | Sin3-associated polypeptide p130
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Histone deacetylase complex subunit SAP130 SINGLE PROTEIN Q9H0E3

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136715
Ensembl ENSG00000136715
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0030914 (STAGA complex)
GO:0070822 (Sin3-type complex)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0004402 (histone acetyltransferase activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0043966 (histone H3 acetylation)
Wikipedia SAP130

Target Cross References - Protein

Human Protein Atlas ENSG00000136715
IntAct Q9H0E3
Open Targets ENSG00000136715
PharmGKB PA143485608
Reactome R-HSA-3214847 (HATs acetylate histones.)
R-HSA-427413 (NoRC negatively regulates rRNA expression.)
UniProt B7ZLM3 C9K0X9 Q4ZFV4 Q53T46 Q8WVW4 Q9H0E3 Q9H9G8

Target Cross References - Domain

InterPro IPR024137 (His_deAcase_cplx_SAP130.)
IPR031963 (SAP130_C.)
Pfam PF16014 (SAP130_C)
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