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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1169600
Target Type SINGLE PROTEIN
Preferred Name Interleukin-5
Synonyms B-cell differentiation factor I | Eosinophil differentiation factor | IL-5 | IL5 | Interleukin-5 | T-cell replacing factor | TRF
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Interleukin-5 SINGLE PROTEIN P05113

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107884 RESLIZUMAB Interleukin-5 inhibitor 4 FDA
CHEMBL2108429 MEPOLIZUMAB Interleukin-5 inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000113525
Ensembl ENSG00000113525
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO Molecular Function GO:0004713 (protein tyrosine kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005125 (cytokine activity)
GO:0005137 (interleukin-5 receptor binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0008284 (positive regulation of cell proliferation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030890 (positive regulation of B cell proliferation)
GO:0043547 (positive regulation of GTPase activity)
GO:0045645 (positive regulation of eosinophil differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046427 (positive regulation of JAK-STAT cascade)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0051024 (positive regulation of immunoglobulin secretion)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0071803 (positive regulation of podosome assembly)
Wikipedia Interleukin_5

Target Cross References - Protein

canSAR P05113
Human Protein Atlas ENSG00000113525
IntAct P05113
Open Targets ENSG00000113525
PharmGKB PA29833
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
UniProt P05113 Q13840

Target Cross References - Domain

InterPro IPR000186 (IL-5.)
IPR009079 (4_helix_cytokine-like_core.)
IPR012351 (4_helix_cytokine_core.)
Pfam PF02025 (IL5)

Target Cross References - Structure

PDBe 1HUL 3QT2 3VA2
CREDO 1HUL 3QT2 3VA2
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