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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1169596
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase A-Raf
Synonyms ARAF | ARAF1 | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | Serine/threonine-protein kinase A-Raf
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase raf family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase A-Raf SINGLE PROTEIN P10398

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559685 RAF serine/threonine protein kinase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545195 LY-3009120 Serine/threonine-protein kinase A-Raf inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000078061
Ensembl ENSG00000078061
GO Cellular Component GO:0005575 (cellular_component)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005057 (receptor signaling protein activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006464 (cellular protein modification process)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0032006 (regulation of TOR signaling)
GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0043066 (negative regulation of apoptotic process)
Wikipedia ARAF

Target Cross References - Protein

canSAR P10398
Human Protein Atlas ENSG00000078061
IntAct P10398
Guide to Pharmacology 1933
Open Targets ENSG00000078061
PharmGKB PA24928
Pharos P10398 (Tbio)
Reactome R-HSA-5673000 (RAF activation.)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-5675221 (Negative regulation of MAPK pathway.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
UniProt P07557 P10398 Q5H9B2 Q5H9B3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR002219 (PE/DAG-bd.)
IPR003116 (RBD_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020454 (DAG/PE-bd.)
IPR029071 (Ubiquitin-rel_dom.)
Pfam PF00130 (C1_1)
PF02196 (RBD)
PF07714 (Pkinase_Tyr)
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