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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1163128
Target Type SINGLE PROTEIN
Preferred Name Microtubule-associated serine/threonine-protein kinase 1
Synonyms KIAA0973 | MAST1 | Microtubule-associated serine/threonine-protein kinase 1 | SAST | Syntrophin-associated serine/threonine-protein kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase mast family

Target Components

Component Description Relationship Accession
Microtubule-associated serine/threonine-protein kinase 1 SINGLE PROTEIN Q9Y2H9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038500 MAST1/MAST2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105613
Ensembl ENSG00000105613
GO Cellular Component GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0035556 (intracellular signal transduction)
Wikipedia MAST1

Target Cross References - Protein

canSAR Q9Y2H9
Human Protein Atlas ENSG00000105613
IntAct Q9Y2H9
Guide to Pharmacology 1510
Open Targets ENSG00000105613
PharmGKB PA134946727
Pharos Q9Y2H9 (Tchem)
UniProt O00114 Q8N6X0 Q9Y2H9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001478 (PDZ.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015022 (MA_Ser/Thr_Kinase_dom.)
IPR023142 (MAST_pre-PK_dom.)
IPR028777 (MAST1.)
Pfam PF00069 (Pkinase)
PF00595 (PDZ)
PF08926 (DUF1908)

Target Cross References - Structure

PDBe 3PS4
CREDO 3PS4
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