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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1163124
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase 13
Synonyms LZK | Leucine zipper-bearing kinase | MAP3K13 | MLK | Mitogen-activated protein kinase kinase kinase 13 | Mixed lineage kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase mlk family > tkl protein kinase lzk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 13 SINGLE PROTEIN O43283

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL290352 CEP-1347 Mitogen-activated protein kinase kinase kinase 13 inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073803
Ensembl ENSG00000073803
GO Cellular Component GO:0005737 (cytoplasm)
GO:0008385 (IkappaB kinase complex)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0006468 (protein phosphorylation)
GO:0007254 (JNK cascade)
GO:0016310 (phosphorylation)
GO:0046777 (protein autophosphorylation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
Wikipedia MAP3K13

Target Cross References - Protein

canSAR O43283
Human Protein Atlas ENSG00000073803
IntAct O43283
Guide to Pharmacology 2073
Open Targets ENSG00000073803
PharmGKB PA30596
Pharos O43283 (Tbio)
UniProt B2R6U2 B4DLE3 B4DMV2 B4DZJ4 D3DNU1 O43283 Q05BY6 Q15450 Q2NKN3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017419 (MAP3K12_MAP3K13.)
IPR027258 (MAPKKK13.)
Pfam PF07714 (Pkinase_Tyr)
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