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Target Report Card

Target Name and Classification

Target ID CHEMBL1163124
Preferred Name Mitogen-activated protein kinase kinase kinase 13
Synonyms LZK | Leucine zipper-bearing kinase | MAP3K13 | MLK | Mitogen-activated protein kinase kinase kinase 13 | Mixed lineage kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase mlk family > tkl protein kinase lzk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 13 SINGLE PROTEIN O43283

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073803
Ensembl ENSG00000073803
GO Cellular Component GO:0005624 (membrane fraction)
GO:0005737 (cytoplasm)
GO:0016020 (membrane)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005524 (ATP binding)
GO:0019901 (protein kinase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0006468 (protein phosphorylation)
GO:0007254 (JNK cascade)
GO:0046777 (protein autophosphorylation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
Wikipedia MAP3K13

Target Cross References - Protein

canSAR O43283
Human Protein Atlas ENSG00000073803
IntAct O43283
PharmGKB PA30596
UniProt B2R6U2 B4DLE3 B4DMV2 B4DZJ4 D3DNU1 O43283 Q05BY6 Q15450 Q2NKN3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017419 (MAP3K12_MAP3K13.)
IPR027258 (MAPKKK13.)
Pfam PF07714 (Pkinase_Tyr)