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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1163120
Target Type SINGLE PROTEIN
Preferred Name Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma
Synonyms PI3K-C2-gamma | PIK3C2G | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma | Phosphoinositide 3-kinase-C2-gamma | PtdIns-3-kinase C2 subunit gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma SINGLE PROTEIN O75747

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000139144
Ensembl ENSG00000139144
GO Cellular Component GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0005829 (cytosol)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0035005 (1-phosphatidylinositol-4-phosphate 3-kinase activity)
GO:0005524 (ATP binding)
GO:0016307 (phosphatidylinositol phosphate kinase activity)
GO:0035091 (phosphatidylinositol binding)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO Biological Process GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0044281 (small molecule metabolic process)
GO:0006468 (protein phosphorylation)
GO:0030168 (platelet activation)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006954 (inflammatory response)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0045087 (innate immune response)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0006644 (phospholipid metabolic process)
GO:0060326 (cell chemotaxis)
GO:0002250 (adaptive immune response)
Wikipedia PIK3C2G

Target Cross References - Protein

Human Protein Atlas ENSG00000139144
Guide to Pharmacology 2288 (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma)
PharmGKB PA33306
UniProt O75747 A1L3U0

Target Cross References - Domain

InterPro IPR000341 (PI3K_Ras-bd_dom.)
IPR000403 (PI3/4_kinase_cat_dom.)
IPR002420 (PI3K_C2_dom.)
IPR015433 (PI_Kinase.)
IPR029071 (Ubiquitin-rel_dom.)
IPR000008 (C2_dom.)
IPR001683 (Phox.)
IPR001263 (PInositide-3_kin_accessory_dom.)
IPR011009 (Kinase-like_dom.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
Pfam PF00613 (PI3Ka)
PF00794 (PI3K_rbd)
PF00787 (PX)
PF00454 (PI3_PI4_kinase)
PF00168 (C2)

Target Cross References - Structure

PDBe 2WWE
CREDO 2WWE
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