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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1163119
Target Type SINGLE PROTEIN
Preferred Name U4/U6 small nuclear ribonucleoprotein Prp4
Synonyms PRP4 homolog | PRP4 | PRPF4 | U4/U6 small nuclear ribonucleoprotein Prp4 | U4/U6 snRNP 60 kDa protein | WD splicing factor Prp4 | hPrp4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
U4/U6 small nuclear ribonucleoprotein Prp4 SINGLE PROTEIN O43172

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136875
Ensembl ENSG00000136875
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005681 (spliceosomal complex)
GO:0015030 (Cajal body)
GO:0016607 (nuclear speck)
GO:0046540 (U4/U6 x U5 tri-snRNP complex)
GO:0071001 (U4/U6 snRNP)
GO:0097525 (spliceosomal snRNP complex)
GO Molecular Function GO:0005515 (protein binding)
GO:0017070 (U6 snRNA binding)
GO:0030621 (U4 snRNA binding)
GO Biological Process GO:0000375 (RNA splicing, via transesterification reactions)
GO:0000398 (mRNA splicing, via spliceosome)
GO:0006396 (RNA processing)
GO:0006397 (mRNA processing)
GO:0008380 (RNA splicing)
Wikipedia PRPF4

Target Cross References - Protein

canSAR O43172
Human Protein Atlas ENSG00000136875
IntAct O43172
Open Targets ENSG00000136875
PharmGKB PA38448
Reactome R-HSA-72163 (mRNA Splicing - Major Pathway.)
UniProt O43172 O43445 O43864 Q5T1M8 Q96DG2 Q96IK4

Target Cross References - Domain

InterPro IPR001680 (WD40_repeat.)
IPR014906 (PRP4-like.)
IPR015943 (WD40/YVTN_repeat-like_dom.)
IPR017986 (WD40_repeat_dom.)
IPR019775 (WD40_repeat_CS.)
IPR020472 (G-protein_beta_WD-40_rep.)
Pfam PF00400 (WD40)
PF08799 (PRP4)

Target Cross References - Structure

PDBe 1MZW
CREDO 1MZW
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