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Target Report Card

Target Name and Classification

Target ID CHEMBL1163112
Preferred Name Cyclin-dependent kinase-like 5
Synonyms CDKL5 | Cyclin-dependent kinase-like 5 | STK9 | Serine/threonine-protein kinase 9
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdkl family

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase-like 5 SINGLE PROTEIN O76039

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000008086
Ensembl ENSG00000008086
GO Cellular Component GO:0005634 (nucleus)
GO:0032839 (dendrite cytoplasm)
GO:0044294 (dendritic growth cone)
GO Molecular Function GO:0004693 (cyclin-dependent protein kinase activity)
GO:0005524 (ATP binding)
GO:0048365 (Rac GTPase binding)
GO Biological Process GO:0001764 (neuron migration)
GO:0032855 (positive regulation of Rac GTPase activity)
GO:0045773 (positive regulation of axon extension)
GO:0046777 (protein autophosphorylation)
GO:0050775 (positive regulation of dendrite morphogenesis)
Wikipedia CDKL5

Target Cross References - Protein

canSAR O76039
CGD Epileptic encephalopathy, early infantile, 2; Rett syndrome, atypical; Angelman-like syndrome
Human Protein Atlas ENSG00000008086
IntAct O76039
Guide to Pharmacology 1986 (cyclin-dependent kinase-like 5)
PharmGKB PA36218
UniProt O76039 Q14198 Q5H985 Q8IYC7 Q9UJL6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)