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Target Report Card

Target Name and Classification

Target ID CHEMBL1163101
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase/endoribonuclease IRE1
Synonyms ERN1 | Endoplasmic reticulum-to-nucleus signaling 1 | Endoribonuclease | IRE1 | IRE1a | Inositol-requiring protein 1 | Ire1-alpha | Serine/threonine-protein kinase | Serine/threonine-protein kinase/endoribonuclease IRE1 | hIRE1p
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase/endoribonuclease IRE1 SINGLE PROTEIN O75460

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000178607
Ensembl ENSG00000178607
GO Cellular Component GO:0030176 (integral to endoplasmic reticulum membrane)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016891 (endoribonuclease activity, producing 5'-phosphomonoesters)
GO Biological Process GO:0006351 (transcription, DNA-dependent)
GO:0006355 (regulation of transcription, DNA-dependent)
GO:0006397 (mRNA processing)
GO:0006915 (apoptosis)
GO:0006917 (induction of apoptosis)
GO:0006987 (activation of signaling protein activity involved in unfolded protein response)
GO:0007050 (cell cycle arrest)
Wikipedia ERN1

Target Cross References - Protein

canSAR O75460
Human Protein Atlas ENSG00000178607
IntAct O75460
Guide to Pharmacology 2020 (endoplasmic reticulum to nucleus signaling 1)
PharmGKB PA27861
Reactome REACT_15380 (Diabetes pathways.)
UniProt A1L457 A8K8N8 A8MXS7 O75460 Q59EE2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR006567 (PUG-dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR010513 (KEN_RNase_activator.)
IPR011009 (Kinase-like_dom.)
IPR011047 (Quino_AlcDH-like.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR018391 (PQQ_beta_propeller_repeat.)
Pfam PF00069 (Pkinase)
PF06479 (Ribonuc_2-5A)

Target Cross References - Structure

PDBe 2HZ6 3P23
CREDO 2HZ6 3P23
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