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Target Report Card

Target Name and Classification

Target ID CHEMBL1163101
Preferred Name Serine/threonine-protein kinase/endoribonuclease IRE1
Synonyms ERN1 | Endoplasmic reticulum-to-nucleus signaling 1 | Endoribonuclease | IRE1 | IRE1a | Inositol-requiring protein 1 | Ire1-alpha | Serine/threonine-protein kinase | Serine/threonine-protein kinase/endoribonuclease IRE1 | hIRE1p
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase/endoribonuclease IRE1 SINGLE PROTEIN O75460

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000178607
Ensembl ENSG00000178607
GO Cellular Component GO:0005637 (nuclear inner membrane)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030176 (integral component of endoplasmic reticulum membrane)
GO:1990332 (Ire1 complex)
GO:1990597 (AIP1-IRE1 complex)
GO:1990604 (IRE1-TRAF2-ASK1 complex)
GO:1990630 (IRE1-RACK1-PP2A complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0003824 (catalytic activity)
GO:0004519 (endonuclease activity)
GO:0004521 (endoribonuclease activity)
GO:0004540 (ribonuclease activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO:0030544 (Hsp70 protein binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043531 (ADP binding)
GO:0046872 (metal ion binding)
GO:0051879 (Hsp90 protein binding)
GO Biological Process GO:0001935 (endothelial cell proliferation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006379 (mRNA cleavage)
GO:0006397 (mRNA processing)
GO:0006402 (mRNA catabolic process)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006986 (response to unfolded protein)
GO:0006987 (activation of signaling protein activity involved in unfolded protein response)
GO:0007050 (cell cycle arrest)
GO:0007257 (activation of JUN kinase activity)
GO:0008152 (metabolic process)
GO:0016241 (regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0030968 (endoplasmic reticulum unfolded protein response)
GO:0033120 (positive regulation of RNA splicing)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0036289 (peptidyl-serine autophosphorylation)
GO:0036498 (IRE1-mediated unfolded protein response)
GO:0046777 (protein autophosphorylation)
GO:0070054 (mRNA splicing, via endonucleolytic cleavage and ligation)
GO:0070055 (mRNA endonucleolytic cleavage involved in unfolded protein response)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0071333 (cellular response to glucose stimulus)
GO:0090502 (RNA phosphodiester bond hydrolysis, endonucleolytic)
GO:1900103 (positive regulation of endoplasmic reticulum unfolded protein response)
GO:1901142 (insulin metabolic process)
GO:1990579 (peptidyl-serine trans-autophosphorylation)
Wikipedia ERN1

Target Cross References - Protein

canSAR O75460
Human Protein Atlas ENSG00000178607
IntAct O75460
Guide to Pharmacology 2020
Open Targets ENSG00000178607
PharmGKB PA27861
Pharos O75460 (Tchem)
Reactome R-HSA-381070 (IRE1alpha activates chaperones.)
UniProt A1L457 A8K8N8 A8MXS7 O75460 Q59EE2

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR010513 (KEN_dom.)
IPR011009 (Kinase-like_dom.)
IPR011047 (Quinoprotein_ADH-like_supfam.)
IPR018391 (PQQ_beta_propeller_repeat.)
IPR018997 (PUB_domain.)
IPR027295 (Quinoprotein_ADH-like_fam.)
Pfam PF00069 (Pkinase)
PF06479 (Ribonuc_2-5A)

Target Cross References - Structure

PDBe 2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI
CREDO 2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI