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Target Report Card

Target Name and Classification

Target ID CHEMBL1075323
Target Type SINGLE PROTEIN
Preferred Name Endoplasmin
Synonyms 94 kDa glucose-regulated protein | Endoplasmin | GRP-94 | GRP94 | HSP90B1 | Heat shock protein 90 kDa beta member 1 | TRA1 | Tumor rejection antigen 1 | gp96 homolog
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Endoplasmin SINGLE PROTEIN P14625

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166598
Ensembl ENSG00000166598
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0030496 (midbody)
GO:0031012 (extracellular matrix)
GO:0034663 (endoplasmic reticulum chaperone complex)
GO:0042470 (melanosome)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0071682 (endocytic vesicle lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003723 (RNA binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0019903 (protein phosphatase binding)
GO:0046790 (virion binding)
GO:0050750 (low-density lipoprotein particle receptor binding)
GO:0051082 (unfolded protein binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0002224 (toll-like receptor signaling pathway)
GO:0006457 (protein folding)
GO:0006898 (receptor-mediated endocytosis)
GO:0006950 (response to stress)
GO:0015031 (protein transport)
GO:0030433 (ER-associated ubiquitin-dependent protein catabolic process)
GO:0030970 (retrograde protein transport, ER to cytosol)
GO:0031247 (actin rod assembly)
GO:0034975 (protein folding in endoplasmic reticulum)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0036500 (ATF6-mediated unfolded protein response)
GO:0043066 (negative regulation of apoptotic process)
GO:0043666 (regulation of phosphoprotein phosphatase activity)
GO:0051208 (sequestering of calcium ion)
GO:0071318 (cellular response to ATP)
Wikipedia HSP90B1

Target Cross References - Protein

canSAR P14625
Human Protein Atlas ENSG00000166598
IntAct P14625
Guide to Pharmacology 2904
Open Targets ENSG00000166598
PharmGKB PA36705
Reactome R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-3000480 (Scavenging by Class A Receptors.)
R-HSA-381183 (ATF6 (ATF6-alpha) activates chaperone genes.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt P14625 Q96A97

Target Cross References - Domain

InterPro IPR001404 (Hsp90_fam.)
IPR003594 (HATPase_C.)
IPR019805 (Heat_shock_protein_90_CS.)
IPR020568 (Ribosomal_S5_D2-typ_fold.)
IPR020575 (Hsp90_N.)
Pfam PF00183 (HSP90)
PF02518 (HATPase_c)

Target Cross References - Structure

PDBe 4NH9
CREDO 4NH9
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