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Target Report Card

Target Name and Classification

Target ID CHEMBL1075314
Preferred Name Vitronectin
Synonyms S-protein | Serum-spreading factor | Somatomedin-B | V75 | VN | VTN | Vitronectin V10 subunit | Vitronectin V65 subunit | Vitronectin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Vitronectin SINGLE PROTEIN P04004

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109072
Ensembl ENSG00000109072
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0031012 (extracellular matrix)
GO:0070062 (extracellular exosome)
GO:0071062 (alphav-beta3 integrin-vitronectin complex)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0005044 (scavenger receptor activity)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0030247 (polysaccharide binding)
GO:0050840 (extracellular matrix binding)
GO Biological Process GO:0006898 (receptor-mediated endocytosis)
GO:0006955 (immune response)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0010811 (positive regulation of cell-substrate adhesion)
GO:0010951 (negative regulation of endopeptidase activity)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0030195 (negative regulation of blood coagulation)
GO:0030198 (extracellular matrix organization)
GO:0030449 (regulation of complement activation)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0032092 (positive regulation of protein binding)
GO:0033627 (cell adhesion mediated by integrin)
GO:0035987 (endodermal cell differentiation)
GO:0048260 (positive regulation of receptor-mediated endocytosis)
GO:0048709 (oligodendrocyte differentiation)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0061302 (smooth muscle cell-matrix adhesion)
GO:0090303 (positive regulation of wound healing)
Wikipedia Vitronectin

Target Cross References - Protein

canSAR P04004
Human Protein Atlas ENSG00000109072
IntAct P04004
Open Targets ENSG00000109072
PharmGKB PA37335
Reactome R-HSA-2129379 (Molecules associated with elastic fibres.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-977606 (Regulation of Complement cascade.)
UniProt B2R7G0 P01141 P04004 Q9BSH7

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001212 (Somatomedin_B_dom.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR020436 (Somatomedin_B_chordata.)
Pfam PF00045 (Hemopexin)
PF01033 (Somatomedin_B)

Target Cross References - Structure

PDBe 1OC0 3BT1 3BT2 4K24
CREDO 1OC0 3BT1 3BT2 4K24