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Target Report Card

Target Name and Classification

Target ID CHEMBL1075180
Preferred Name CD81 antigen
Synonyms 26 kDa cell surface protein TAPA-1 | CD81 antigen | CD81 | CD_antigen=CD81 | TAPA1 | TSPAN28 | Target of the antiproliferative antibody 1 | Tetraspanin-28 | Tspan-28
Organism Homo sapiens
Species Group No
Protein Target Classification
  • surface antigen

Target Components

Component Description Relationship Accession
CD81 antigen SINGLE PROTEIN P60033

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110651
Ensembl ENSG00000110651
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0031982 (vesicle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0023026 (MHC class II protein complex binding)
GO:1990459 (transferrin receptor binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0007166 (cell surface receptor signaling pathway)
GO:0008104 (protein localization)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0016032 (viral process)
GO:0030449 (regulation of complement activation)
GO:0030890 (positive regulation of B cell proliferation)
GO:0031623 (receptor internalization)
GO:0031647 (regulation of protein stability)
GO:0043128 (positive regulation of 1-phosphatidylinositol 4-kinase activity)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046718 (viral entry into host cell)
GO:0046813 (receptor-mediated virion attachment to host cell)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050776 (regulation of immune response)
GO:0061462 (protein localization to lysosome)
GO:0071404 (cellular response to low-density lipoprotein particle stimulus)
GO:1904352 (positive regulation of protein catabolic process in the vacuole)
GO:2000145 (regulation of cell motility)
Wikipedia CD81

Target Cross References - Protein

canSAR P60033
CGD Immunodeficiency, common variable, 6
Human Protein Atlas ENSG00000110651
IntAct P60033
Open Targets ENSG00000110651
PharmGKB PA26240
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-977606 (Regulation of Complement cascade.)
UniProt P18582 P60033 Q5U0J6

Target Cross References - Domain

InterPro IPR000301 (Tetraspanin.)
IPR008952 (Tetraspanin_EC2_sf.)
IPR018499 (Tetraspanin/Peripherin.)
IPR018503 (Tetraspanin_CS.)
Pfam PF00335 (Tetraspannin)

Target Cross References - Structure

PDBe 1G8Q 1IV5 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX
CREDO 1G8Q 1IV5 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX