ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1075165
Target Type SINGLE PROTEIN
Preferred Name Phosphatidylinositol 3-kinase catalytic subunit type 3
Synonyms PI3-kinase type 3 | PI3K type 3 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVps34
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylinositol 3-kinase catalytic subunit type 3 SINGLE PROTEIN Q8NEB9

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000078142
Ensembl ENSG00000078142
GO Cellular Component GO:0005768 (endosome)
GO:0005770 (late endosome)
GO:0005776 (autophagosome)
GO:0005829 (cytosol)
GO:0005930 (axoneme)
GO:0005942 (phosphatidylinositol 3-kinase complex)
GO:0016020 (membrane)
GO:0030496 (midbody)
GO:0030670 (phagocytic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0035032 (phosphatidylinositol 3-kinase complex, class III)
GO:0045335 (phagocytic vesicle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016303 (1-phosphatidylinositol-3-kinase activity)
GO:0016740 (transferase activity)
GO:0035004 (phosphatidylinositol 3-kinase activity)
GO Biological Process GO:0000045 (autophagosome assembly)
GO:0000910 (cytokinesis)
GO:0006468 (protein phosphorylation)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006914 (autophagy)
GO:0007032 (endosome organization)
GO:0007049 (cell cycle)
GO:0016236 (macroautophagy)
GO:0016310 (phosphorylation)
GO:0016485 (protein processing)
GO:0032465 (regulation of cytokinesis)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
GO:0042149 (cellular response to glucose starvation)
GO:0043201 (response to leucine)
GO:0045022 (early endosome to late endosome transport)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0050708 (regulation of protein secretion)
GO:0051301 (cell division)
Wikipedia PIK3C3

Target Cross References - Protein

canSAR Q8NEB9
Human Protein Atlas ENSG00000078142
IntAct Q8NEB9
Guide to Pharmacology 2152
Open Targets ENSG00000078142
PharmGKB PA33307
Pharos Q8NEB9 (Tchem)
Reactome R-HSA-109704 (PI3K Cascade.)
R-HSA-1632852 (Macroautophagy.)
R-HSA-1660514 (Synthesis of PIPs at the Golgi membrane.)
R-HSA-1660516 (Synthesis of PIPs at the early endosome membrane.)
R-HSA-1660517 (Synthesis of PIPs at the late endosome membrane.)
R-HSA-168138 (Toll Like Receptor 9 (TLR9) Cascade.)
R-HSA-5668599 (RHO GTPases Activate NADPH Oxidases.)
UniProt Q15134 Q8NEB9

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000403 (PI3/4_kinase_cat_dom.)
IPR001263 (PInositide-3_kin_accessory_dom.)
IPR002420 (PI3K_C2_dom.)
IPR008290 (PI3K_Vps34.)
IPR011009 (Kinase-like_dom.)
IPR015433 (PI_Kinase.)
IPR016024 (ARM-type_fold.)
IPR018936 (PI3/4_kinase_CS.)
Pfam PF00454 (PI3_PI4_kinase)
PF00613 (PI3Ka)
PF00792 (PI3K_C2)

Target Cross References - Structure

PDBe 3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN
CREDO 3IHY 3LS8 4OYS 4PH4 4UWF 4UWG 4UWH 4UWK 4UWL 5ANL 5ENN
spacer
spacer