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Target Report Card

Target Name and Classification

Target ID CHEMBL1075157
Preferred Name Diacylglycerol kinase gamma
Synonyms DAG kinase gamma | DAGK3 | DGK-gamma | DGKG | Diacylglycerol kinase gamma | Diglyceride kinase gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Diacylglycerol kinase gamma SINGLE PROTEIN P49619

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000058866
Ensembl ENSG00000058866
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004143 (diacylglycerol kinase activity)
GO:0005509 (calcium ion binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0016310 (phosphorylation)
GO:0030168 (platelet activation)
GO:0035556 (intracellular signal transduction)
GO:0048666 (neuron development)
Wikipedia DGKG

Target Cross References - Protein

Human Protein Atlas ENSG00000058866
IntAct P49619
Open Targets ENSG00000058866
PharmGKB PA27314
Reactome R-HSA-114508 (Effects of PIP2 hydrolysis.)
UniProt B2RAH4 P49619 Q2M1H4 Q5FWG1

Target Cross References - Domain

InterPro IPR000756 (Diacylglycerol_kin_accessory.)
IPR001206 (Diacylglycerol_kinase_cat_dom.)
IPR002048 (EF_hand_dom.)
IPR002219 (PE/DAG-bd.)
IPR011992 (EF-hand-dom_pair.)
IPR016064 (NAD/diacylglycerol_kinase.)
IPR018247 (EF_Hand_1_Ca_BS.)
IPR029477 (DAG_kinase_typeI_N.)
Pfam PF00130 (C1_1)
PF00609 (DAGK_acc)
PF00781 (DAGK_cat)
PF13499 (EF-hand_7)
PF14513 (DAG_kinase_N)