ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1075153
Target Type SINGLE PROTEIN
Preferred Name Tumor necrosis factor receptor superfamily member 10B
Synonyms CD_antigen=CD262 | DR5 | Death receptor 5 | KILLER | TNF-related apoptosis-inducing ligand receptor 2 | TNFRSF10B | TRAIL receptor 2 | TRAIL-R2 | TRAILR2 | TRICK2 | Tumor necrosis factor receptor superfamily member 10B | ZTNFR9
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Tumor necrosis factor receptor superfamily member 10B SINGLE PROTEIN O14763

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743080 TIGATUZUMAB Tumor necrosis factor receptor superfamily member 10B agonist 3 PubMed PubMed
CHEMBL1743003 CONATUMUMAB Tumor necrosis factor receptor superfamily member 10B agonist 2 PubMed
CHEMBL1743008 DROZITUMAB Tumor necrosis factor receptor superfamily member 10B agonist 2 PubMed
CHEMBL2107846 DULANERMIN Tumor necrosis factor receptor superfamily member 10B agonist 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000120889
Ensembl ENSG00000120889
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004872 (receptor activity)
GO:0005031 (tumor necrosis factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0045569 (TRAIL binding)
GO Biological Process GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007250 (activation of NF-kappaB-inducing kinase activity)
GO:0007275 (multicellular organism development)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0032496 (response to lipopolysaccharide)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0042127 (regulation of cell proliferation)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0071260 (cellular response to mechanical stimulus)
GO:0097296 (activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO:1902041 (regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
Wikipedia TNFRSF10B

Target Cross References - Protein

CGD Squamous cell carcinoma, head and neck
Human Protein Atlas ENSG00000120889
IntAct O14763
Guide to Pharmacology 1880
Open Targets ENSG00000120889
PharmGKB PA36598
Reactome R-HSA-140534 (Ligand-dependent caspase activation.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-3371378 (Regulation by c-FLIP.)
R-HSA-5213460 (RIPK1-mediated regulated necrosis.)
R-HSA-5218900 (CASP8 activity is inhibited.)
R-HSA-6803211 (TP53 Regulates Transcription of Death Receptors and Ligands.)
R-HSA-69416 (Dimerization of procaspase-8.)
R-HSA-75158 (TRAIL signaling.)
UniProt O14720 O14763 O15508 O15517 O15531 Q6UXM8 Q7Z360 Q9BVE0

Target Cross References - Domain

InterPro IPR000488 (Death_domain.)
IPR001368 (TNFR/NGFR_Cys_rich_reg.)
IPR011029 (DEATH-like_dom.)
IPR020465 (TNFR_10.)
IPR034024 (TNFRSF10_N.)
IPR034029 (TNFRSF10A/B_death.)
Pfam PF00020 (TNFR_c6)
PF00531 (Death)

Target Cross References - Structure

PDBe 1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2
CREDO 1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2
spacer
spacer