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Target Report Card

Target Name and Classification

Target ID CHEMBL1075149
Preferred Name Cystine/glutamate transporter
Synonyms Amino acid transport system xc- | Calcium channel blocker resistance protein CCBR1 | Cystine/glutamate transporter | SLC7A11 | Solute carrier family 7 member 11 | xCT
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc03 and slc07 families of heteromeric amino acid transporters (hats) > slc07 cationic amino acid transporter/glycoprotein-associated family

Target Components

Component Description Relationship Accession
Cystine/glutamate transporter SINGLE PROTEIN Q9UPY5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000151012
Ensembl ENSG00000151012
GO Cellular Component GO:0005791 (rough endoplasmic reticulum)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0005515 (protein binding)
GO:0015171 (amino acid transmembrane transporter activity)
GO:0015327 (cystine:glutamate antiporter activity)
GO Biological Process GO:0003333 (amino acid transmembrane transport)
GO:0006810 (transport)
GO:0006865 (amino acid transport)
GO:0006979 (response to oxidative stress)
GO:0007420 (brain development)
GO:0009636 (response to toxic substance)
GO:0035094 (response to nicotine)
GO:0050900 (leukocyte migration)
GO:0070306 (lens fiber cell differentiation)
GO:0070527 (platelet aggregation)
GO:0089711 (L-glutamate transmembrane transport)
Wikipedia SLC7A11

Target Cross References - Protein

Human Protein Atlas ENSG00000151012
IntAct Q9UPY5
Guide to Pharmacology 902
Open Targets ENSG00000151012
PharmGKB PA35919
Reactome R-HSA-210991 (Basigin interactions.)
R-HSA-352230 (Amino acid transport across the plasma membrane.)
UniProt A8K2U4 Q9UPY5

Target Cross References - Domain

InterPro IPR002293 (AA/rel_permease1.)
IPR004760 (L_AA_transporter.)
Pfam PF13520 (AA_permease_2)