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Target Report Card

Target Name and Classification

Target ID CHEMBL1075132
Preferred Name Heat shock protein 75 kDa, mitochondrial
Synonyms HSP 75 | HSP75 | Heat shock protein 75 kDa, mitochondrial | TNFR-associated protein 1 | TRAP-1 | TRAP1 | Tumor necrosis factor type 1 receptor-associated protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Heat shock protein 75 kDa, mitochondrial SINGLE PROTEIN Q12931

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000126602
Ensembl ENSG00000126602
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005758 (mitochondrial intermembrane space)
GO:0005759 (mitochondrial matrix)
GO:0005811 (lipid particle)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005164 (tumor necrosis factor receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0019901 (protein kinase binding)
GO:0044822 (poly(A) RNA binding)
GO:0051082 (unfolded protein binding)
GO Biological Process GO:0006457 (protein folding)
GO:0006950 (response to stress)
GO:0009386 (translational attenuation)
GO:0061077 (chaperone-mediated protein folding)
GO:1901856 (negative regulation of cellular respiration)
GO:1902176 (negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)
GO:1903427 (negative regulation of reactive oxygen species biosynthetic process)
GO:1903751 (negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)
Wikipedia TRAP1

Target Cross References - Protein

canSAR Q12931
Human Protein Atlas ENSG00000126602
IntAct Q12931
Guide to Pharmacology 2909
Open Targets ENSG00000126602
PharmGKB PA36781
Reactome R-HSA-611105 (Respiratory electron transport.)
UniProt B4DR68 D3DUC8 F5H897 O43642 O75235 Q12931 Q9UHL5

Target Cross References - Domain

InterPro IPR001404 (Hsp90_fam.)
IPR003594 (HATPase_C.)
IPR020568 (Ribosomal_S5_D2-typ_fold.)
IPR020575 (Hsp90_N.)
Pfam PF00183 (HSP90)

Target Cross References - Structure

PDBe 4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH
CREDO 4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH