ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1075129
Target Type SINGLE PROTEIN
Preferred Name Cofilin-1
Synonyms 18 kDa phosphoprotein | CFL | CFL1 | Cofilin, non-muscle isoform | Cofilin-1 | p18
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Cofilin-1 SINGLE PROTEIN P23528

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172757
Ensembl ENSG00000172757
GO Cellular Component GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005925 (focal adhesion)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO:0016363 (nuclear matrix)
GO:0030027 (lamellipodium)
GO:0030864 (cortical actin cytoskeleton)
GO:0031258 (lamellipodium membrane)
GO:0031982 (vesicle)
GO:0032587 (ruffle membrane)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003779 (actin binding)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0051015 (actin filament binding)
GO Biological Process GO:0000281 (mitotic cytokinesis)
GO:0001755 (neural crest cell migration)
GO:0001842 (neural fold formation)
GO:0006468 (protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0007015 (actin filament organization)
GO:0007266 (Rho protein signal transduction)
GO:0009615 (response to virus)
GO:0022604 (regulation of cell morphogenesis)
GO:0030010 (establishment of cell polarity)
GO:0030036 (actin cytoskeleton organization)
GO:0030042 (actin filament depolymerization)
GO:0030043 (actin filament fragmentation)
GO:0030836 (positive regulation of actin filament depolymerization)
GO:0035722 (interleukin-12-mediated signaling pathway)
GO:0043066 (negative regulation of apoptotic process)
GO:0043200 (response to amino acid)
GO:0044794 (positive regulation by host of viral process)
GO:0061001 (regulation of dendritic spine morphogenesis)
Wikipedia Cofilin_1

Target Cross References - Protein

canSAR P23528
Human Protein Atlas ENSG00000172757
IntAct P23528
Open Targets ENSG00000172757
PharmGKB PA26423
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-2029482 (Regulation of actin dynamics for phagocytic cup formation.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-5627117 (RHO GTPases Activate ROCKs.)
R-HSA-8950505 (Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation.)
UniProt B3KUQ1 P23528 Q53Y87 Q9UCA2

Target Cross References - Domain

InterPro IPR002108 (ADF-H.)
IPR017904 (ADF/Cofilin.)
IPR027234 (Cofilin_1.)
IPR029006 (ADF-H/Gelsolin-like_dom_sf.)
Pfam PF00241 (Cofilin_ADF)

Target Cross References - Structure

PDBe 4BEX 5HVK 5L6W
CREDO 4BEX 5HVK 5L6W
spacer
spacer