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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075126
Target Type SINGLE PROTEIN
Preferred Name Pyruvate kinase isozymes R/L
Synonyms PK1 | PKL | PKLR | Pyruvate kinase 1 | Pyruvate kinase PKLR | Pyruvate kinase isozymes L/R | R-type/L-type pyruvate kinase | Red cell/liver pyruvate kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Pyruvate kinase PKLR SINGLE PROTEIN P30613

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143627 ENSG00000262785
Ensembl ENSG00000143627 ENSG00000262785
GO Cellular Component GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0003824 (catalytic activity)
GO:0004743 (pyruvate kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030955 (potassium ion binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0005975 (carbohydrate metabolic process)
GO:0006096 (glycolytic process)
GO:0006754 (ATP biosynthetic process)
GO:0007584 (response to nutrient)
GO:0008152 (metabolic process)
GO:0009408 (response to heat)
GO:0009749 (response to glucose)
GO:0010038 (response to metal ion)
GO:0010226 (response to lithium ion)
GO:0014070 (response to organic cyclic compound)
GO:0016310 (phosphorylation)
GO:0032869 (cellular response to insulin stimulus)
GO:0033198 (response to ATP)
GO:0042866 (pyruvate biosynthetic process)
GO:0051591 (response to cAMP)
GO:0061621 (canonical glycolysis)
Wikipedia PKLR

Target Cross References - Protein

canSAR P30613
CGD Pyruvate kinase deficiency
Human Protein Atlas ENSG00000143627 ENSG00000262785
IntAct P30613
Open Targets ENSG00000143627 ENSG00000262785
PharmGKB PA33352
Pharos P30613 (Tbio)
Reactome R-HSA-163765 (ChREBP activates metabolic gene expression.)
R-HSA-210745 (Regulation of gene expression in beta cells.)
R-HSA-70171 (Glycolysis.)
UniProt O75758 P11973 P30613

Target Cross References - Domain

InterPro IPR001697 (Pyr_Knase.)
IPR011037 (Pyrv_Knase-like_insert_dom.)
IPR015793 (Pyrv_Knase_brl.)
IPR015794 (Pyrv_Knase_a/b.)
IPR015795 (Pyrv_Knase_C.)
IPR015806 (Pyrv_Knase_insert_dom.)
IPR015813 (Pyrv/PenolPyrv_Kinase-like_dom.)
IPR018209 (Pyrv_Knase_AS.)
Pfam PF00224 (PK)
PF02887 (PK_C)

Target Cross References - Structure

PDBe 2VGB 2VGF 2VGG 2VGI 4IMA 4IP7
CREDO 2VGB 2VGF 2VGG 2VGI 4IMA 4IP7
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