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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075126
Target Type SINGLE PROTEIN
Preferred Name Pyruvate kinase isozymes R/L
Synonyms PK1 | PKL | PKLR | Pyruvate kinase 1 | Pyruvate kinase PKLR | Pyruvate kinase isozymes L/R | R-type/L-type pyruvate kinase | Red cell/liver pyruvate kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Pyruvate kinase PKLR SINGLE PROTEIN P30613

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143627
Ensembl ENSG00000143627
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004743 (pyruvate kinase activity)
GO:0005524 (ATP binding)
GO:0030955 (potassium ion binding)
GO Biological Process GO:0006096 (glycolysis)
GO:0006112 (energy reserve metabolic process)
GO:0031018 (endocrine pancreas development)
GO:0031325 (positive regulation of cellular metabolic process)
Wikipedia PKLR

Target Cross References - Protein

canSAR P30613
CGD Pyruvate kinase deficiency
Human Protein Atlas ENSG00000143627
IntAct P30613
PharmGKB PA33352
Reactome REACT_13698 (Regulation of beta-cell development.)
REACT_1505 (Integration of energy metabolism.)
REACT_474 (Metabolism of carbohydrates.)
UniProt P11973 P30613

Target Cross References - Domain

InterPro IPR001697 (Pyr_Knase.)
IPR011037 (Pyrv_Knase-like_insert_dom.)
IPR015793 (Pyrv_Knase_brl.)
IPR015794 (Pyrv_Knase_a/b.)
IPR015795 (Pyrv_Knase_C-like.)
IPR015806 (Pyrv_Knase_insert_dom.)
IPR015813 (Pyrv/PenolPyrv_Kinase.)
IPR018209 (Pyrv_Knase_AS.)
Pfam PF00224 (PK)
PF02887 (PK_C)

Target Cross References - Structure

PDBe 2VGB 2VGF 2VGG 2VGI
CREDO 2VGB 2VGF 2VGG 2VGI
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